NCT04512456Recruiting
Cardiovascular Responses to Exercise in People Living With HIV/AIDS: Effects of Exercise Training
Autonomic and Hemodynamic Responses to Muscular Ergoreflex Activation in People Living With HIV/AIDS: Effects of Exercise Training.
Source: ClinicalTrials.gov · Last updated 27 Mar 2026
Brief summary (registry, in English)
Patients living with HIV (PLWHIV) have compromised muscle metaboreflex, which can cause exercise intolerance. This randomized controlled clinical trial will verify the effects of regular exercise on autonomic and hemodynamic responses to muscle ergoreflex activation in these patients. PLWHIV without regular physical exercise will be randomly assigned into an exercise training or a control group. The exercise training group will undergo regular physical exercise during 12 weeks (60-min session performed 3 times/wk with moderate intensity), while the control group will keep inactive. Another group consisted of inactive HIV-uninfected group will be included. The primary endpoints will be blood pressure and autonomic markers in response to the Stroop Color-Word Test and the activation of muscle ergoreflex, by means of the post-exercise circulatory arrest (PECA), which will be performed with and without the topical application of a capsaicin-based analgesic balm. Secondary endpoints will include heart rate, peripheral vascular resistance, stroke volume, cardiac output, blood lactate concentration, anthropometrics, and handgrip strength. The active and inactive PLWHIV groups will be evaluated before and after the exercise training, while the healthy group only at baseline.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 63 (estimated)
- First submitted
- 7 Aug 2020
- Start date
- 1 Aug 2024
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- Instituto Nacional de Cardiologia de Laranjeiras
- Diseases
- HIV
- NCT number
- NCT04512456
What you commit to
- Study type: Interventional
- Planned participants: 63
- From 1 Aug 2024 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- using pacemakers and/or antidepressant, antiarrhythmic or antihypertensive medication, especially beta-blockers.
Other illness
- presence of coronary artery disease, ischemic diseases, pulmonary disease, diabetes, Chagas disease, tuberculosis, heart failure, hypertension;
Other
- regular physical exercise;
- malnutrition;
Who the study is looking for
- diagnosis of HIv infection for at least 5 years;
- use of combined antiretroviral therapy for at least 3 years;
- asymptomatic and free from opportunistic diseases at enrollment.
Age in the registry: 30 years to 50 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Rio de Janeiro State University Coordinator of this site? Confirm its status | Rio de Janeiro | Brazil | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.