NCT04512690Completed
Spinal Cord Stimulation for Restoration of Arm and Hand Function in People With Subcortical Stroke
Source: ClinicalTrials.gov · Last updated 28 Sept 2026
Brief summary (registry, in English)
The goal of this study is to verify whether electrical stimulation of the cervical spinal cord can activate muscles of the arm and hand in people with hemiplegia following stroke. Participants will undergo a surgical procedure to implant a system which provides epidural electrical stimulation (EES) of the cervical spinal cord. Researchers will quantify the ability of EES to recruit arm and hand muscles and produce distinct kinematic movements. The implant will be removed after less than 30 days. Results of this study will provide the foundation for future studies evaluating the efficacy of a minimally-invasive neuro-technology that can be used in clinical neurorehabilitation programs to restore upper limb motor function in people with subcortical strokes, thereby increasing independence and quality of life.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 8 (actual)
- First submitted
- 24 Jul 2020
- Start date
- 24 Mar 2021
- Primary completion date
- 30 Jun 2025
- Lead sponsor
- Lee Fisher, PhD
- Diseases
- Stroke
- NCT number
- NCT04512690
What you commit to
- Study type: Interventional
- Participants enrolled: 8
- From 24 Mar 2021 to the primary completion date, 30 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Receiving anticoagulant, anti-spasticity or anti-epileptic medications throughout the duration of the study.
Other illness
- Serious disease or disorder (ex. neurological condition other than stroke, cancer, severe cardiac or respiratory disease, renal failure, etc.) or cognitive impairments that could affect the ability to participate in study activities.
Other
- Pregnancy or breast feeding.
- Presence of any implanted medical devices.
- Severe claustrophobia.
- Presence of joint contractures deemed by study clinician/investigator to be too severe to participate in study activities
- Results from the Brief Symptoms Inventory (BSI-18) and additional discussions with the Principal Investigator and a study physician that deem participant inappropriate for the study.
- Evaluation to sign consent form score \<12.
Who the study is looking for
- Single, ischemic or hemorrhagic stroke resulting in upper extremity hemiparesis more than 6 months prior to the time of enrollment. (Prior strokes that did not cause upper extremity motor deficits are not exclusionary.)
- Participants must be between the ages of 21 and 70 years old.
- Scores higher than 7 and lower than 50 on the Fugl-Meyer scale
Age in the registry: 21 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Pittsburgh Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.