NCT04513808RecruitingPhase 3
Total Intravenous Anesthesia and Recurrence Free Survival
Total IntraVenous AnesthesIa and ReCurrence-free Survival AfTer EsOphageal CanceR SurgerY
Source: ClinicalTrials.gov · Last updated 8 Sept 2026
Brief summary (registry, in English)
The investigators propose to compare recurrence-free survival in patients having potentially curative (Stages 1-3) surgery for esophageal cancer who will be randomly assigned to propofol-based total intravenous anesthesia or sevoflurane-based balanced general anesthesia.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 1614 (estimated)
- First submitted
- 12 May 2020
- Start date
- 15 Aug 2020
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- The Cleveland Clinic
- Diseases
- Gastric and esophageal cancer
- NCT number
- NCT04513808
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 1614
- From 15 Aug 2020 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous surgery for esophageal cancer (except diagnostic biopsies) Age \<18 or \>85 years old.
Other illness
- Other cancer not believed by the attending surgeon to be in long-term remission.
- Systemic disease believed by the attending surgeon to present ≥25% two- year mortality.
Other
- ASA Physical Status ≥4.
- Any contraindication to propofol or sevoflurane.
Who the study is looking for
- Primary esophageal cancer without known extension beyond the esophagus. (i.e. believed to be Tumor Stage 1-3).
- Scheduled for potentially curative esophageal cancer surgery.
- Written informed consent, including willingness to be randomized to intravenous versus volatile anesthesia.
Age in the registry: 18 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Shanhai Chest Hospital Coordinator of this site? Confirm its status | Shanghai | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.