NCT04517565Active, not recruiting
Longitudinal Neuroimaging in Sturge-Weber Syndrome
Source: ClinicalTrials.gov · Last updated 19 Aug 2026
Brief summary (registry, in English)
In this project the accuracy of a novel, rapid magnetic resonance imaging (MRI) approach to detect brain abnormalities in patients with Sturge-Weber syndrome (SWS) will be tested; this new imaging approach, that can create multiple types of MR images in about 5 minutes, without contrast administration (and sedation even in young children), can be also readily applied in other pediatric brain disorders in the future. The investigators will also study how advanced MRI, including susceptibility-weighted and diffusion tensor imaging can detect detailed signs of brain vascular and neuronal reorganization that helps improve neurological and cognitive outcome of children and young adults with SWS, who could benefit from targeted interventions in the future to minimize neurocognitive deficits in affected patients. All enrolled subjects will undergo advanced brain MRI and neurocognitive evaluation to achieve these goals.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 80 (estimated)
- First submitted
- 7 Aug 2020
- Start date
- 1 Mar 2020
- Primary completion date
- 28 Feb 2026
- Lead sponsor
- Wayne State University
- NCT number
- NCT04517565
What you commit to
- Study type: Interventional
- Planned participants: 80
- From 1 Mar 2020 to the primary completion date, 28 Feb 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of severe claustrophobia, precluding staying still in the scanner for up to 30 minutes.
- History of sensitivity to MRI contrast material;
- History of renal disease that would preclude safe administration of MRI contrast material
Other
- For all subjects:
- Metal in the head or mouth that would preclude safe, artifact-free MRI scanning; or any other metal or electronic device contraindicated for MRI scanning.
- Pregnancy (pregnant women will be scheduled for the study after delivery).
- For SWS subjects, who will receive MRI contrast material, additional exclusion criteria:
Who the study is looking for
- Subjects with Sturge-Weber syndrome (SWS):
- Age 3 months - 30 years;
- Presence of a facial port-wine birthmark (PWB) indicating a risk for SWS and/or evidence of SWS brain involvement based on the presence of one or more intracranial SWS brain abnormalities from previous clinical imaging (MRI or computed tomography) scan(s) with or without a facial PWB. SWS brain abnormalities can include both brain vascular and/or parenchymal abnormalities (including atrophy, calcification, etc.);
- In children who will undergo formal neuropsychology testing including detailed language testing (age 3 years and above): proficiency of English language.
- Healthy control subjects:
- Age 3 years - 30 years;
- No history of neurological or psychiatric disorder
Age in the registry: 3 months to 30 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Wayne State University/Children's Hospital of Michigan Coordinator of this site? Confirm its status | Detroit | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.