Brain Activation and Satiety in Children 2

Prior treatment

• Presence of any implanted metal or metal devices, including ferro-metallic surgical clips or orthodontic braces;
• Current use of medications known to alter appetite, body weight, or brain response
• Use of weight loss medications (child participant) within 3 months of screening visit.

Other illness

• History of acute or chronic serious medical conditions;
• known diabetes mellitus or recent (6 mo.) history of anemia;
• Documented cognitive disorder, disruptive behavior, inability to participate in group sessions;
• Food intolerance to test meal (macaroni and cheese) or vegetarianism/veganism or severe food allergies.
• History of gastroparesis, pancreatitis or gallstones (unless status post cholecystectomy);
• Family history of multiple endocrine neoplasia type 2 or familial medullary thyroid carcinoma;
• Untreated thyroid disorder or adrenal insufficiency;

Lab values

• Known renal impairment (GFR\<60 ml/min/1.73m2)

Other

• Claustrophobia;
• Known elevated calcitonin level at phone screening or increased measured calcitonin level at study visits;
• Participating parent is pregnant

• 10-12 years of age
• Male or female
• Ability and willingness to participate in study visits including fMRI scans, blood draws, and weekly injections;
• Parent willing to provide informed written consent and child willing to provide written assent;
• Child has BMI z-score \>95th percentile. for age and sex;
• One parent that is obese or overweight (BMI \>27 kg/m2); willingness of 1 parent (does not have to be the parent with obesity) to engage in weekly family-based weight control treatment delivered in English.