NCT04530916CompletedPhase 1/2
Wild Blueberries and Cardiovascular Health in Middle-aged/Older Men and Postmenopausal Women
Antihypertensive and Vascular-Protective Effects of Wild Blueberries in Middle-Aged/Older Men and Postmenopausal Women.
Source: ClinicalTrials.gov · Last updated 30 Oct 2026
Brief summary (registry, in English)
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Aging is the primary risk factor for CVD, in large part due to adverse modifications to the arteries. These modifications include vascular endothelial dysfunction and arterial stiffness. Vascular endothelial dysfunction is an initiating step in atherosclerosis, and is primarily caused by reduced nitric oxide (NO) bioavailability secondary to excessive superoxide-driven oxidative stress and inflammation. Endothelial dysfunction leads to arterial stiffness and the development of hypertension (HTN) which further increases CVD. Greater than 2/3 of the US population has elevated blood pressure or stage 1-HTN. As such, interventions that improve vascular endothelial dysfunction by increasing NO bioavailability and mitigating excessive oxidative stress and inflammation are needed. Blueberries are rich in bioactive compounds including flavonoids, phenolic acids, and pterostilbene. These compounds and their metabolites have been shown to attenuate oxidative stress and inflammation. The primary goal of this study is to assess the efficacy of blueberries to improve reduce blood pressure and improve vascular endothelial dysfunction and arterial stiffness in middle-aged/older men with elevated blood pressure or stage 1-HTN.
- Status (registry)
- Completed
- Phase (registry)
- Phase 1/2
- Study type
- Interventional
- Enrollment
- 60 (actual)
- First submitted
- 27 Jan 2020
- Start date
- 1 Jan 2020
- Primary completion date
- 31 Mar 2025
- Lead sponsor
- Colorado State University
- Diseases
- High blood pressure
- NCT number
- NCT04530916
What you commit to
- Study type: Interventional · Phase 1/2
- Participants enrolled: 60
- From 1 Jan 2020 to the primary completion date, 31 Mar 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Taking \> 1 antihypertensive medication, taking 1 antihypertensive medication more than 1 time per day, and/or taking the antihypertensive medication for \< 3 months
- Testosterone or estrogen replacement therapy use 6 months prior to study start
- Antibiotic therapy within past two months
Other illness
- Diagnosed cancer, cardiovascular disease, diabetes, or gastrointestinal, kidney, liver, lung, and/or pancreatic disease
- Current smokers or history of smoking in the past 12 months
- Allergies or contraindication to study treatments or procedures
Lab values
- Triglycerides \> 350 mg/dL, low-density lipoprotein cholesterol (LDL-C) ≥ 190 mg/dL, hemoglobin A1c ≥ 6.5%, and/or taking a lipid-lowering or glucose-lowering medication
Other
- Have had a menstrual cycle within the past year
- Blood Pressure \< 120 (systolic BP) or ≥ 140/90 mm Hg
- Reactive hyperemia index \> 3.00%
- Weight change ≥ 3 kg in the past 3 months, actively trying to lose weight, or unwilling to remain weight stable throughout the study
- Binge and/or heavy drinker (\>3 drinks on any given occasion and/or \>7 drinks/week for women, and \>4 drinks on any given occasion and/or \>14 drinks/week for men)
- Body mass index \< 18.5 or \> 40 kg/m2
Who the study is looking for
- Men and postmenopausal women
- Aged 45-70 years
- Elevated blood pressure or stage 1-Hypertension
- Ability to provide informed consent
Age in the registry: 40 years to 75 years · Sex: Male · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Food and Nutrition Clinical Research Laboratory Coordinator of this site? Confirm its status | Fort Collins | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.