NCT04532606RecruitingPhase 4
Impact of Remimazolam on Prognosis After Bladder Cancer Surgery
Impact of Remimazolam Tosilate for General Anesthesia on Prognosis After Bladder Cancer Surgery: a Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 30 Jul 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Bladder cancer is one of the most common genitourinary cancers. Transurethral resection of bladder tumor (TURBT) is the standard therapy for nonmuscle invasive bladder cancer. However, patients after TURBT are at risk for recurrence and progression. Benzodiazepines are proved to inhibit proliferation of multiple types of cancer cells in vitro. Delirium is an acute onset and transient cerebral dysfunction and is associated with worse outcomes. Previous studies indicated that benzodiazepines increase incidence of postoperative delirium. Remimazolam is a new benzodiazepine with rapid onset and ultra-short activity. The aims of this study are to explore the impact of remimazolam for general anesthesia on emergency delirium and recurrence-free survival in patients undergoing bladder cancer surgery.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 1128 (estimated)
- First submitted
- 25 Aug 2020
- Start date
- 5 Feb 2021
- Primary completion date
- 31 Oct 2025
- Lead sponsor
- Peking University First Hospital
- Diseases
- Bladder cancer
- NCT number
- NCT04532606
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 1128
- From 5 Feb 2021 to the primary completion date, 31 Oct 2025
- 6 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Emergent surgery;
- Use of benzodiazepines for 1 week within the last month before surgery;
- The purpose of surgery is to make a diagnosis or preoperative judgement is that tumor cannot be completely removed.
Other illness
- Combined with other malignant tumors;
- Preoperative history of schizophrenia, epilepsy, parkinsonism or myasthenia gravis;
- Inability to communicate in the preoperative period due to coma, profound dementia, language barrier, or end-stage disease;
- Critical illness (preoperative American Society of Anesthesiologists physical status classification ≥IV), severe hepatic dysfunction (Child-Pugh class C), or severe renal dysfunction (undergoing dialysis before surgery);
Other
- Refuse to participate;
Who the study is looking for
- Age ≥50 years and \<90 years;
- Preoperative diagnosis is non-muscle-invasive bladder cancer(Ta-T1);
- Scheduled to undergo transurethral resection of bladder tumor;
- Agree to participate, and provide written informed consent.
Age in the registry: 50 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (6)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Peking University First Hospital Coordinator of this site? Confirm its status | Beijin | China | Recruiting |
| The Sixth Medical Center of PLA General Hospital Coordinator of this site? Confirm its status | Beijing | China | Recruiting |
| Beijing Tsinghua Chang Gung Hospital Coordinator of this site? Confirm its status | Beijing | China | Recruiting |
| Guizhou Provincial People's Hospital Coordinator of this site? Confirm its status | Guiyang | China | Recruiting |
| Jiangsu Provincial People's Hospital Coordinator of this site? Confirm its status | Nanjing | China | Recruiting |
| Shanghai 10th People's Hospital Coordinator of this site? Confirm its status | Shanghai | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.