NCT04535999CompletedPhase 4
Open Label Study of the Effects of Secukinumab on Nail Psoriasis and Non-Invasive Measures of Enthesitis (Phase IV)
Phase IV Open Label Study of the Effects of Secukinumab on Nail Psoriasis and Non-Invasive Measures of Enthesitis
Source: ClinicalTrials.gov · Last updated 30 Oct 2026
Brief summary (registry, in English)
This study will be an open label study of secukinumab for the treatment of nail psoriasis. Secukinumab is an FDA-approved treatment for psoriasis. We will examine time to response and different methods of defining nail disease response.
- Status (registry)
- Completed
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 16 (actual)
- First submitted
- 27 Aug 2020
- Start date
- 7 Feb 2022
- Primary completion date
- 30 May 2025
- Lead sponsor
- University of Pennsylvania
- Diseases
- Psoriasis
- NCT number
- NCT04535999
What you commit to
- Study type: Interventional · Phase 4
- Participants enrolled: 16
- From 7 Feb 2022 to the primary completion date, 30 May 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Metal implants or other concerns for use of MRI
Other illness
- History of IL-17 inhibitor use (other therapies including TNF inhibitors or non- biologics DMARDS in the past are acceptable)
- Inflammatory bowel disease
- Active infection
- Patients may have a history of self-reported psoriatic arthritis but may not have active PsA at the time of screening.
Other
- We will exclude patients with onychomyosis of the fingernails on clippings
Who the study is looking for
- Active psoriatic nail disease defined as a Minimum 4 or more fingernails OR NAPSI\>20
- Active skin psoriasis currently (no minimum PASI or BSA) or skin psoriasis in the past documented by a dermatologist
- Age 18-85
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital at the University of Pennsylvania Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.