NCT04541056Active, not recruiting
Goal Management Training for Adult Survivors of Childhood Leukemia and Non-Hodgkins Lymphoma With Neurocognitive Sequelae
The Effect of Goal Management Training for Adult Survivors of Childhood Leukemia and Non-Hodgkins Lymphoma With Neurocognitive Sequelae: A Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 19 Aug 2025
Brief summary (registry, in English)
Survivors of childhood cancer are at risk for developing neurocognitive sequelae. Multiple meta-analyses demonstrate significant deficits in overall intellectual abilities, academic functioning and specific cognitive skills among survivors of childhood cancer treated with intrathecal chemotherapy only and/or cranial irradiation. Preventing neurocognitive deficits is therefore of great importance. Unfortunately, intervention studies for this group of survivors are scarce. The main aim of this randomized controlled trial is to determine the efficacy of Goal Management Training (GMT) as a group-based treatment program for 60 adult survivors of childhood leukemia, and non Hodgkins lymphoma, diagnosed between 1980 and 2017 at an age below 18, with attention and executive function deficits. The participants will be randomized to one treatment group (GMT), and one waitlist condition followed by one active control intervention, the "Brain health workshop" (BHW), which has a psycho-educative approach. The follow-up time from diagnosis will be ≥5 years and the age at survey 18-40 years. The study will expand the knowledge base on treatment factors important in improving cognitive function. Results from this study can be implemented in rehabilitation for the young adult survivors of childhood leukemia, and non Hodgkins lymphoma, which will be of importance for their future educational and work-related functioning.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 1 Sept 2020
- Start date
- 4 Sept 2020
- Primary completion date
- Feb 2026
- Lead sponsor
- Norwegian University of Science and Technology
- NCT number
- NCT04541056
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 4 Sept 2020 to the primary completion date, Feb 2026
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Cancer recurrence within the last five years
- A history of premorbid Central Nervous System (CNS) injury or disease (e.g., Traumatic brain injury with noticeable cognitive changes, loss of consciousness or injury discovered on CT or MR)
- Pre-existing attention deficit hyperactivity disorder (ADHD)
- A major psychiatric disease and/or ongoing substance abuse impeding study participation
- Down syndrome
Other
- Motor or sensory damage impeding study participation
- Present suicidal ideation
Who the study is looking for
- Screening/baseline:
- Written informed consent
- ≥5 years from diagnosis
- Age 18-40
- Without cancer recurrence the last five years
- Understand and speak Norwegian
- Additional inclusion criteria for the intervention:
- Experiencing executive dysfunction as determined by a semi-structured interview
- Cognitive capacity to engage with the training, and General Ability Index (GAI) Score ≥70 measured by Wechsler Intelligence Scale for Adults (WAIS-IV)
Criteria the registry did not label
- The Norwegian Cancer Registry will identify participants based on the following criteria:
- Acute Lymphoblastic Leukaemia (ALL), Acute Myelogen Leukemia (AML), non Hodgkins Lymphoma diagnosed between 1980 - 2017
- Age when diagnosed \<18 år (0-17years)
- Age at survey 18-40 years
- Born between 1980 - 2004
- Minimum five years (≥5) post ALL, AML, NHL diagnosis
- ALL, AML, NHL treatment at Oslo University Hospital and St. Olavs Hospital
Age in the registry: 18 years to 40 years · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Oslo University Hospital, Rikshospitalet Coordinator of this site? Confirm its status | Oslo | Norway | Unknown status |
| Department of Psychology, Norwegian University of Science and Technology (NTNU) Coordinator of this site? Confirm its status | Trondheim | Norway | Unknown status |
| St Olavs Hospital Coordinator of this site? Confirm its status | Trondheim | Norway | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.