NCT04543773Active, not recruiting
Individualized Targeting and Neuromodulation of Late-Life Depression
Source: ClinicalTrials.gov · Last updated 9 Oct 2026
Brief summary (registry, in English)
An open-label, single-arm, clinical research study about how to make transcranial magnetic stimulation (TMS), an FDA-approved treatment, more effective for patients with late-life depression using fMRI.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 24 (estimated)
- First submitted
- 29 Jun 2020
- Start date
- 1 Oct 2024
- Primary completion date
- 1 Nov 2026
- Lead sponsor
- University of New Mexico
- Diseases
- Depression
- NCT number
- NCT04543773
What you commit to
- Study type: Interventional
- Planned participants: 24
- From 1 Oct 2024 to the primary completion date, 1 Nov 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior neurosurgical procedure
- History of any previous TMS treatment
Other illness
- Current diagnosis of bipolar disorder, schizophrenia, schizoaffective disorder, or any other psychotic disorder
- Substance use disorder, abuse or dependence, with active use within the last 3 months
- Unstable medical illness, or hospitalization within 3 weeks of study entry
- Current diagnosis of a neurological disorder or neurocognitive disorder
- History of seizure
- History of ECT treatment within the past three months
Other
- Legal or mental incompetency, or inability to consent to study
- Any contraindication to obtaining magnetic resonance imaging safely
- Pregnant women
- Inability to complete the protocol, namely, inability to independently attend all study visits and TMS sessions on time.
Who the study is looking for
- Participant must be at least 60 years of age (all genders, races, and ethnicities), and less than or equal to 79 years of age.
- Participant must have a diagnosis of major depressive disorder without psychosis for the past 6 months, as diagnosed by a board-certified psychiatrist
- Must show evidence of being in a current major depressive episode, as indicated by score on QIDS-C of 10 or higher.
- Participant must not have any conditions listed in the exclusion criteria
- Participant must be fluent in English
Age in the registry: 60 years to 79 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of New Mexico HSC Coordinator of this site? Confirm its status | Albuquerque | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.