NCT04545489Completed
A Nurse-led Intervention to Extend the Veteran HIV Treatment Cascade for Cardiovascular Disease Prevention
A Nurse-led Intervention to Extend the Veteran HIV Treatment Cascade for Cardiovascular Disease Prevention (V-EXTRA-CVD)
Source: ClinicalTrials.gov · Last updated 30 Oct 2025
Brief summary (registry, in English)
The VA is the largest single provider of HIV care in the US and Veterans with HIV use significantly more healthcare services and have a 1.5-2x higher risk of atherosclerotic cardiovascular disease (ASCVD) compared to uninfected Veterans. The goal is to improve BP treatment for Veterans with HIV to reduce ASCVD risk. Within a randomized controlled trial (RCT), the investigators hypothesize that the VA adapted nurse-led intervention will result in a clinically significant 6 millimeters of mercury (mmHg) reduction in systolic blood pressure (SBP) over 12 months compared to those receiving enhanced education only. The study is innovative because of the use of stakeholder-engaged design process, multi-component nurse-led intervention, and VA Video Connect (VVC) to monitor CVD risk factors. The project meets VA strategic priorities including: 1) greater choice for Veterans; 2) improve timeliness of services; 3) focus more resources more efficiently (strengthen foundational services in VA). If shown to be effective, this intervention will have substantial impact among high-risk Veterans, potentially reducing ASCVD events by more than a quarter.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 305 (actual)
- First submitted
- 3 Sept 2020
- Start date
- 1 Dec 2020
- Primary completion date
- 1 Oct 2024
- Lead sponsor
- VA Office of Research and Development
- Diseases
- HIV, High blood pressure
- NCT number
- NCT04545489
What you commit to
- Study type: Interventional
- Participants enrolled: 305
- From 1 Dec 2020 to the primary completion date, 1 Oct 2024
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- In-patient psychiatric care
- Diagnosis of dementia or active psychosis
- Terminal illness with life expectancy \< 4 months (ex. Metastatic cancer, Hospice care)
- Recent (\<90day) hospitalization for coronary artery bypass surgery (CABG), myocardial infarction (MI), stroke)
Other
- Severely hearing or speech impaired, or other disability that would limit participation
- In a nursing home at baseline and/or any long-term care facility. Individuals will be censored at the point of entering nursing home care
- Pregnant, breast-feeding, or planning a pregnancy during the study period
- Planning to move out of the area in the next 12 months.
- No reliable access to telephone services
Who the study is looking for
- Age =\> 18 years
- Confirmed HIV+ diagnosis
- Undetectable HIV viral load: defined as the most recent HIV viral load \< 200 copies/mL, checked within the past 18 months (assessed via chart abstraction)
- Hypertension: defined as the average of 4 most recent outpatient BP measurements in the last 18 months to show systolic BP 130 and/or diastolic 90 mmHg (assessed via chart abstraction)
- Veteran at one of the sites participating in the study
- Regular access to a computer, tablet or smart phone device with internet.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Louis Stokes VA Medical Center, Cleveland, OH Coordinator of this site? Confirm its status | Cleveland | United States | Unknown status |
| Atlanta VA Medical and Rehab Center, Decatur, GA Coordinator of this site? Confirm its status | Decatur | United States | Unknown status |
| Durham VA Medical Center, Durham, NC Coordinator of this site? Confirm its status | Durham | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.