NCT04549155Completed
Network-guided TMS in Early Alzheimer's Disease
Using Network-guided TMS to Ameliorate Memory Deficits in Early Alzheimer's Disease
Source: ClinicalTrials.gov · Last updated 27 Oct 2026
Brief summary (registry, in English)
The proposed research will test a novel network-based neurostimulation approach using MRI-derived measures of brain connectivity to establish target sites for neurostimulation and test for the enhancement of memory function beyond a sham stimulation condition. This will be tested in cohort of MCI adults using network-based transcranial magnetic stimulation (TMS) to assess for behavioral improvement due to the controlled intervention. This study will provide important evidence towards the efficacy of neuromodulatory treatments for memory decline and will accelerate the discovery of potent non-invasive treatments to remediate cognitive decline in cognitively impaired older adults.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 37 (actual)
- First submitted
- 9 Sept 2020
- Start date
- 8 Mar 2022
- Primary completion date
- 27 Jun 2025
- Lead sponsor
- Duke University
- Diseases
- Alzheimer disease
- NCT number
- NCT04549155
What you commit to
- Study type: Interventional
- Participants enrolled: 37
- From 8 Mar 2022 to the primary completion date, 27 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Increased risk of seizure for any reason, including prior diagnosis of epilepsy, seizure disorder, increased intracranial pressure, or history of significant head trauma with loss of consciousness for ≥ 30 minutes.
Other illness
- History of any Axis I DSM-IV disorder
- Current or past history of substance abuse or dependence (excluding nicotine)
- Intracranial implants (e.g. aneurysms clips, shunts, stimulators, cochlear implants, or electrodes), cardiac pacemakers, or vagus Nerve stimulation device
- Neurological disorder including, but not limited to: space occupying brain lesion; any history of seizures, history of cerebrovascular accident; fainting, cerebral aneurysm,
- Dementia, Hungtington chorea; Multiple Sclerosis.
- Current use of medications known to lower the seizure threshold and/or affect working memory
- Current or past history of substance abuse or dependence (excluding nicotine)
Other
- Women who are pregnant or breast feeding
- Women who are pregnant or breast feeding
Who the study is looking for
- Elderly: age between 60-82
- English speaking
- Willing to provide consent
- Signed HIPAA authorization
- Use of effective method of birth control for women of childbearing capacity
- Clinical Consensus for MCI
Age in the registry: 60 years to 82 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Duke University Medical Center Coordinator of this site? Confirm its status | Durham | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.