NCT04551872Completed
RESILIENCE: Personalizing Cardiovascular Health
Personalizing Cardiovascular Health: A Population Approach to Promoting CVD Resistance and Resilience Among Individuals With Obesity
Source: ClinicalTrials.gov · Last updated 24 Apr 2024
Brief summary (registry, in English)
Obesity is a rapidly growing epidemic that is associated with the development of cardiovascular disease (CVD). However, some individuals with obesity appear to be resistant to CVD, and other individuals demonstrate resilience to obesity and CVD risk factors. The investigator's overall objective is to understand factors contributing to the heterogeneity of CVD resistance and resilience among individuals with obesity at Duke.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 598 (actual)
- First submitted
- 9 Sept 2020
- Start date
- 22 Sept 2020
- Primary completion date
- 22 Mar 2023
- Lead sponsor
- Duke University
- Diseases
- Obesity
- NCT number
- NCT04551872
What you commit to
- Study type: Interventional
- Participants enrolled: 598
- From 22 Sept 2020 to the primary completion date, 22 Mar 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior bariatric surgery
Other
- Participants "opted out" of being contacted for research in Maestro Care
- Pregnant at the time of enrollment or \<12 months post-partum
Who the study is looking for
- Adults 40-75 years old
- At least one clinic encounter at Duke with BMI record in the EHR within previous year
- Has a current primary care provider listed listed in EHR
- No prior history of ASCVD, as defined by ICD9, ICD10, and CPT codes for coronary artery disease, myocardial infarction, stroke, peripheral arterial disease, prior revascularization for coronary, cerebral, or peripheral arteries.
- Fall into 1 of 4 categories: 200 participants with obesity (BMI ≥ 30) and high 10-year ASCVD risk (≥20%), 200 participants with obesity (BMI ≥ 30) and low 10-year ASCVD risk (\<7.5%), 100 participants with normal weight (BMI 18-25) and high 10-year ASCVD risk (≥20%), and 100 participants with normal weight (BMI 18-25) and low 10-year ASCVD risk (\<7.5%).
- Have internet access
- Have an email address listed in the EHR
- Have access to MyChart
- Have a smartphone
- Be able to read and understand English
Age in the registry: 40 years to 75 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Duke University Health System Coordinator of this site? Confirm its status | Durham | United States | Unknown status |
Related publications
- Design and Rationale of the pERSonalized cardIovascuLar dIsease prEvention, treatmeNt, and CarE (RESILIENCE) study.Contemp Clin Trials · 2026 · PMID 42248410
- Messaging Modality and Content for Recruitment of Research Participants: A Randomized Clinical Trial.JAMA Netw Open · 2026 · PMID 42172031
- Audiovisual Augmentation of Electronic Consent to Improve Consent Rates and Comprehension: A Randomized Clinical Trial.JAMA Netw Open · 2026 · PMID 42060306
This page is information, not medical advice. Discuss any trial with your doctor.