NCT04556045Completed
Exercise Therapy and Radiation Therapy (EXERT) for Metastatic Prostate Cancer
Source: ClinicalTrials.gov · Last updated 17 Sept 2026
Brief summary (registry, in English)
This study is being done to determine if patients receiving personalized exercise therapy (versus those who do not receive personalized exercise therapy) have improved quality of life and physical functioning after completing their radiation therapy. Second, the study is being done to find if the quality of life changes during therapy correlate with measurements of inflammation in the blood. Third, the study is being done to see if adding exercise therapy to radiation therapy will improve survival.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 21 (actual)
- First submitted
- 28 Jul 2020
- Start date
- 11 Dec 2023
- Primary completion date
- 21 May 2026
- Lead sponsor
- Case Comprehensive Cancer Center
- Diseases
- Prostate cancer
- NCT number
- NCT04556045
What you commit to
- Study type: Interventional
- Participants enrolled: 21
- From 11 Dec 2023 to the primary completion date, 21 May 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Performing \> 90 minutes/week of exercise therapy prior at time of enrollment
- History of acute coronary syndromes (including myocardial infarction and unstable angina), coronary angioplasty or stenting within the past 6 months prior to the start of radiation therapy
- Uncontrolled arrhythmias; patients with rate-controlled atrial fibrillation for \>1 month prior to start of radiation therapy may be eligible
- In-patient receiving radiation therapy for a radiation emergency (e.g. cord compression, Superior vena cava (SVC) syndrome, brain metastases)
Other illness
- Cardiac exclusion criteria:
- Class II, III or IV heart failure as defined by the New York Heart Association (NYHA) functional classification system
- thrombosis of lower extremities
- respiratory failure
- acute non-cardiopulmonary disorder that may affect exercise performance or be aggravated by exercise
- Mental impairment leading to inability to complete study requirements
Age
- Children (the protocol will only include men age 18 and older)
Other
- Evidence in the medical record of an absolute contraindication for exercise
- syncope
- acute myocarditis, pericarditis, or endocarditis
- acute pulmonary embolus or pulmonary infarction
- suspected dissecting aneurysm
- pulmonary edema
- High risk of fracture or spine instability (Mirels score ≥7, SINS ≥7)
Who the study is looking for
- Subjects must have lymph node positive or metastatic disease consistent with prostate cancer
- Males ≥18 years of age receiving RT
- Patient receiving 5 fractions or stereotactic body radiation therapy (SBRT)
- Patient may have received prior hormone therapy. Prior or current use of chemotherapy agents is allowed, but not necessary.
- Fluent in written and spoken English
- Must be able to provide and understand informed consent
- Must have an ECOG Performance Status (PS) of ≤ 3
- Primary attending radiation oncologist approval
Age in the registry: 18 years to - · Sex: Male · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center Coordinator of this site? Confirm its status | Cleveland | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.