NCT04557176Active, not recruiting
TB Screening Improves Preventive Therapy Uptake
TB Screening Improves Preventive Therapy Uptake Trial
Source: ClinicalTrials.gov · Last updated 10 Jun 2025
Brief summary (registry, in English)
HIV-infected people have an increased risk of developing active tuberculosis (TB). To reduce the burden of TB among people living with HIV (PLHIV), the World Health Organization (WHO) recommends systematic TB screening followed by 1) confirmatory TB testing for all those who screen positive and 2) TB preventive therapy (TPT) for all TPT-eligible PLHIV who screen negative. The objective of the TB Screening Improves Preventive Therapy Uptake (TB SCRIPT) trial is to determine whether TB screening based on C-reactive protein (CRP) levels, measured using a rapid and low-cost point-of-care (POC) assay, improves TPT uptake and clinical outcomes of PLHIV, relative to symptom-based TB screening.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 1719 (actual)
- First submitted
- 14 Sept 2020
- Start date
- Nov 2020
- Primary completion date
- Sept 2025
- Lead sponsor
- University of California, San Francisco
- Diseases
- Tuberculosis, HIV
- NCT number
- NCT04557176
What you commit to
- Study type: Interventional
- Participants enrolled: 1719
- From Nov 2020 to the primary completion date, Sept 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Actively taking any internationally-approved medication for TB treatment for any reason, within 2 weeks of study entry
- Prior history of combined ART for HIV treatment for any duration (does not include single-dose ART for prevention of vertical transmission of HIV)
Other illness
- Currently resides 25 km outside their enrollment site, plans to move 25 km outside their enrollment site in the next 2 years, or plans to transfer their HIV care from their current enrollment site
Other
- Completed treatment for active pulmonary or extra-pulmonary TB within the past 2 years
- Completed a full course of TPT within the past year
Who the study is looking for
- Age ≥ 18 years
- Confirmed HIV+ test result
- CD4 T lymphocyte count of ≤ 350 cells/μL
- Capacity to provide written (or witnessed verbal, if illiterate) informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Kampala Capital City Authority Clinic Coordinator of this site? Confirm its status | Kampala | Uganda | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.