NCT04558398Completed
Impact of Exercise on Mitochondria in Cancer Patients.
The Impact of Short-term Exercise Programs on Mitochondrial Activity in Colorectal and Prostate Cancer Patients.
Source: ClinicalTrials.gov · Last updated 29 Apr 2026
Brief summary (registry, in English)
The aim is to investigate the impact of prostate and colorectal cancer on mitochondrial quantity and quality along with muscle mass and function and whether this can be modified through the use of a home-based short-term exercise training program. The investigators aim to recruit participants awaiting curative surgery for colorectal and prostate cancer and to assess the variation in baseline mitochondrial activity between them. Participants from both cancer types will then carry out a 4 week home exercise program, this will be randomly allocated to either resistance-based or high-intensity interval training based. Participants will then be re-assessed on the day of their planned surgical procedure to assess the changes effected by the training program. The investigators hypothesize that there will be variation in mitochondrial activity linked to muscle mass across the two cancer types and that home-based exercise programs have the ability to improve mitochondrial activity along with muscle mass.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 15 (actual)
- First submitted
- 14 Feb 2020
- Start date
- 5 Aug 2021
- Primary completion date
- 30 Dec 2023
- Lead sponsor
- University of Nottingham
- Diseases
- Prostate cancer, Colorectal cancer
- NCT number
- NCT04558398
What you commit to
- Study type: Interventional
- Participants enrolled: 15
- From 5 Aug 2021 to the primary completion date, 30 Dec 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Cerebrovascular disease:
- Previous stroke h. Aneurysm (large vessel or intracranial) i. Epilepsy
- Those requiring or receiving neoadjuvant chemotherapy
Other illness
- Active cardiovascular disease:
- Uncontrolled hypertension (BP \> 160/100)
- Angina
- Heart failure (class III/IV)
- Significant arrhythmia
- Right to left cardiac shunt
- Recent cardiac event
- Respiratory disease including:
- Pulmonary hypertension k. Significant COPD l. Uncontrolled asthma
- Significant musculoskeletal or neurological disorders
Other
- Current participation in a formal exercise regime
- Inability to complete exercise training
- Inadequate level of the English language to be able to provide consent
- A BMI \<16.5 or \>35 kg/m2
- Taking beta-adrenergic blocking agents
- Clotting dysfunction or current use of anticoagulants (eg Warfarin/Clopidogrel/ Rivaroxaban)
- Female patients
Who the study is looking for
- Aged 50 years and over (no upper age limit)
- Male patients
- Histologically confirmed malignancy, radiologically or direct visualisation leading to high clinical suspicion of cancer with planned surgical resection as treatment option (prostate or colorectal).
- Sufficient mobility to be able to complete a home-based exercise program
- Capacity to give informed and written consent
- Ability to travel to the RDH to complete the assessment session
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Thomas Smart Coordinator of this site? Confirm its status | Derby | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.