Pharmacological Modulation of Hippocampal Activity in Psychosis 2

Prior treatment

• Current use of psychotropic or potentially psychoactive prescription medication.

Other illness

• Current medical or neurological illness.
• History of severe head trauma.
• Meets criteria for diagnosis of substance or alcohol use disorder within the past month.
• Conditions that preclude MR scanning (as defined in the Screening Form)
• Conditions that preclude study drug administration (as defined in the Screening Form)
• Major psychiatric disorder as determined by Diagnostic and Statistical Manual -5 (major depression, bipolar disorder, obsessive compulsive disorder, post-traumatic stress disorder, etc)

Age

• Age less than 18 or greater than 65.

Other

• Not communicative in English.
• Unable to provide written informed consent.
• BMI \< 17.5 or \> 45.
• Positive urine pregnancy test during the study.
• Breastfeeding/nursing at time of screening or at any time during the study.
• All of the above and in addition:

• Men and women age 18 - 65.
• Communicative in English.
• Provide voluntary, written informed consent.
• Physically healthy by medical history.
• BMI \> 17.5 and \< 45.
• Diagnosis of a psychotic disorder confirmed by Structured Clinical Interview for Diagnostic and Statistical Manual-5 (SCID) or diagnostic interview with a trained clinician.
• Stable medication regimen over at least the past two weeks, including the use of either an oral or intramuscular administration of an antipsychotic medication.
• For females, no longer of child-bearing potential, or agreeing to practice effective contraception during the study (e.g., established use of oral, injected or implanted hormonal methods of contraception; placement of an intrauterine device or intrauterine system; barrier methods: condom with spermicidal foam/gel/film/cream/suppository or occlusive cap \[diaphragm or cervical/vault caps\] with spermicidal foam/gel/film/cream/suppository; male partner sterilization; or true abstinence when this is in line with the preferred and usual lifestyle of the subject); and,
• For females of child-bearing potential, must have a negative urine pregnancy test before MRI and drug administration.
• Not breastfeeding/nursing at time of screening or at any time during the study.
• 1\. All of the above except for subjects will be psychiatrically healthy and not taking psychotropic or potentially psychoactive prescription medication.
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