NCT04567108Completed
Health Effects of Substituting Sugary Beverages With Artificially-sweetened Beverages or Water
SUBstituting With Preferred Options: Health Effects of Substituting Sugar-sweetened Beverages With Non-caloric Beverages in Adults With Overweight and Obesity
Source: ClinicalTrials.gov · Last updated 17 Jul 2026
Brief summary (registry, in English)
Sugar-sweetened beverages (SSBs) contribute an alarming \~7% of calories in the US diet among adults, making SSBs the single largest source of added sugar. However, whether artificially sweetened beverages are a healthful alternative for reducing SSB intake among habitual SSB consumers is unknown. Therefore, the investigators will conduct a 4-arm randomized diet intervention trial to test the effects of substituting SSBs with calorie-free alternatives on body weight and health, among habitual SSB consumers with overweight/obesity.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 461 (actual)
- First submitted
- 14 Sept 2020
- Start date
- 22 Apr 2021
- Primary completion date
- 21 May 2026
- Lead sponsor
- Brigham and Women's Hospital
- Diseases
- Obesity
- NCT number
- NCT04567108
What you commit to
- Study type: Interventional
- Participants enrolled: 461
- From 22 Apr 2021 to the primary completion date, 21 May 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Medication that may affect weight or other study endpoints
Other illness
- Major medical illness (known cardiovascular disease, cancer, kidney disease, cirrhosis, etc.)
Lab values
- Physician diagnosis of T2D or fasting glucose ≥126 mg/dL at in-person screening visit
Other
- Intention to move away from greater Boston area within 1 year from randomization
- Phenylketonuria (PKU)
- Another family or household member participating in the study
- Pregnant in the past 12 months, currently breastfeeding, or planning to become pregnant during the study period
Who the study is looking for
- Adults aged 20-69 years
- Consume ≥1 serving/day (12 oz.) of SSBs (SSBs include soda, fruit drinks, energy drinks, sports drinks, and sweetened waters, sweetened with high fructose corn syrup, sucrose, or fruit juices. SSBs do not include 100% fruit juice, sweetened teas, or flavored milk.)
- BMI 25.0 to 45.0 kg/m2
- Access to a smartphone and willingness and ability to download study app
- Willing to consume beverages consistent with any of the 4 possible group assignments for 6 months
Age in the registry: 20 years to 69 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Brigham and Women's Hospital Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.