NCT04567615CompletedPhase 2
A Study of Relatlimab in Combination With Nivolumab in Participants With Advanced Liver Cancer Who Have Never Been Treated With Immuno-oncology Therapy After Prior Treatment With Tyrosine Kinase Inhibitors
A Phase 2, Randomized, Open-label Study of Relatlimab in Combination With Nivolumab in Participants With Advanced Hepatocellular Carcinoma Who Are Naive to IO Therapy But Progressed on Tyrosine Kinase Inhibitors (RELATIVITY-073)
Source: ClinicalTrials.gov · Last updated 8 Jan 2026
Brief summary (registry, in English)
The purpose of this study is to evaluate the effectiveness and safety of relatlimab in combination with nivolumab in participants with advanced liver cancer who have never been treated with immuno-oncology therapy, after prior treatment with tyrosine kinase inhibitor therapy.
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 266 (actual)
- First submitted
- 24 Sept 2020
- Start date
- 4 Feb 2021
- Primary completion date
- 31 Aug 2023
- Lead sponsor
- Bristol-Myers Squibb
- Diseases
- Liver and biliary tract cancer
- NCT number
- NCT04567615
- EU CT number
- 2023-503519-13-00
- EudraCT number
- 2018-003151-38
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 266
- From 4 Feb 2021 to the primary completion date, 31 Aug 2023
- 61 sites in 17 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior organ allograft or allogeneic bone marrow transplantation
- Have received one or two lines of tyrosine kinase inhibitor therapies
- Evidence of radiographic progression on or after the last line of tyrosine kinase inhibitor therapy
- Other protocol-defined inclusion/exclusion criteria apply
Other illness
- No uncontrolled or significant cardiovascular disease
- No active known autoimmune disease
Other
- Known fibrolamellar HCC, sarcomatoid HCC, combined hepatocellular cholangiocarcinoma
Who the study is looking for
- Must have a diagnosis of hepatocellular carcinoma (HCC) based on histological confirmation
- Must have advanced/metastatic HCC
- Have to be immunotherapy treatment-naive in the advanced/metastatic setting
- Must have at least one Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 measurable untreated lesion
- Child-Pugh score of 5 or 6
- Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1 for ECOG performance status scale
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (61)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Local Institution - 0019 Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Local Institution - 0010 Coordinator of this site? Confirm its status | Ciudad de Buenos Aires | Argentina | Unknown status |
| Local Institution - 0017 Coordinator of this site? Confirm its status | Rosario | Argentina | Unknown status |
| Local Institution - 0063 Coordinator of this site? Confirm its status | San Miguel de Tucumán | Argentina | Unknown status |
| Local Institution - 0016 Coordinator of this site? Confirm its status | Barretos | Brazil | Unknown status |
| Local Institution - 0025 Coordinator of this site? Confirm its status | Belo Horizonte | Brazil | Unknown status |
| Local Institution - 0060 Coordinator of this site? Confirm its status | Porto Alegre | Brazil | Unknown status |
| Unidade de Pesquisa Clínica do Hospital da Clínicas de Ribeirão Preto-Clinical Oncology Coordinator of this site? Confirm its status | Ribeirão Preto | Brazil | Unknown status |
| Local Institution - 0015 Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| Local Institution - 0018 Coordinator of this site? Confirm its status | Santiago | Chile | Unknown status |
| Local Institution - 0029 Coordinator of this site? Confirm its status | Santiago | Chile | Unknown status |
| Local Institution - 0024 Coordinator of this site? Confirm its status | Temuco | Chile | Unknown status |
| Local Institution - 0114 Coordinator of this site? Confirm its status | Changsha | China | Unknown status |
| Local Institution - 0117 Coordinator of this site? Confirm its status | Hangzhou | China | Unknown status |
| Local Institution - 0113 Coordinator of this site? Confirm its status | Harbin | China | Unknown status |
| Local Institution - 0107 Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
| Local Institution - 0108 Coordinator of this site? Confirm its status | Xi'an | China | Unknown status |
| Local Institution - 0118 Coordinator of this site? Confirm its status | Xi'an | China | Unknown status |
| Masaryk Memorial Cancer Institute Coordinator of this site? Confirm its status | Brno-Stred | Czechia | Completed |
| Hospital Clinic de Barcelona Coordinator of this site? Confirm its status | Barcelona | Spain | Completed |
| Hospital Universitario Reina Sofia Coordinator of this site? Confirm its status | Córdoba | Spain | Completed |
| Hospital Universitario Donostia Coordinator of this site? Confirm its status | Donostia | Spain | Completed |
| Hospital General Universitario Gregorio Marañón Coordinator of this site? Confirm its status | Madrid | Spain | Completed |
| Hospital Universitario 12 de Octubre Coordinator of this site? Confirm its status | Madrid | Spain | Completed |
| University Clinic of Navarra Coordinator of this site? Confirm its status | Pamplona | Spain | Completed |
| Hopital Beaujon Coordinator of this site? Confirm its status | Clichy | France | Completed |
| Centre Hospitalier Universitaire Grenoble Alpes Coordinator of this site? Confirm its status | Grenoble Cedex 9 | France | Completed |
| Hopital De La Croix-Rousse Coordinator of this site? Confirm its status | Lyon Cedex 04 | France | Completed |
| Centre Hospitalier Universitaire de Bordeaux Coordinator of this site? Confirm its status | Pessac | France | Completed |
| CHRU De Nancy Coordinator of this site? Confirm its status | Vandoeuvre Les Nancy | France | Completed |
| Local Institution - 0077 Coordinator of this site? Confirm its status | Hksar | Hong Kong SAR China | Unknown status |
| Local Institution - 0079 Coordinator of this site? Confirm its status | Shatin | Hong Kong SAR China | Unknown status |
| Local Institution - 0075 Coordinator of this site? Confirm its status | Ishikawa | Japan | Unknown status |
| Local Institution - 0071 Coordinator of this site? Confirm its status | Kyoto | Japan | Unknown status |
| Local Institution - 0072 Coordinator of this site? Confirm its status | Matsuyama | Japan | Unknown status |
| Local Institution - 0045 Coordinator of this site? Confirm its status | Ōsaka-sayama | Japan | Unknown status |
| Local Institution - 0076 Coordinator of this site? Confirm its status | Yokohama | Japan | Unknown status |
| Local Institution - 0054 Coordinator of this site? Confirm its status | Yokohama | Japan | Unknown status |
| Local Institution - 0020 Coordinator of this site? Confirm its status | Seongnam-si | South Korea | Unknown status |
| Local Institution - 0011 Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
| Local Institution - 0043 Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
| Local Institution - 0100 Coordinator of this site? Confirm its status | Cuauhtémoc | Mexico | Unknown status |
| Local Institution - 0106 Coordinator of this site? Confirm its status | Oaxaca City | Mexico | Unknown status |
| Local Institution - 0101 Coordinator of this site? Confirm its status | San Luis Potosí City | Mexico | Unknown status |
| Local Institution - 0003 Coordinator of this site? Confirm its status | Auckland | New Zealand | Unknown status |
| Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki W Krakowie Coordinator of this site? Confirm its status | Cracow | Poland | Completed |
| Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy Coordinator of this site? Confirm its status | Warsaw | Poland | Completed |
| Fundeni Clinical Institute Coordinator of this site? Confirm its status | Bucharest | Romania | Completed |
| Institute Of Oncology Prof. Dr. Ion Chiricuta Cluj-Napoca Coordinator of this site? Confirm its status | Cluj-Napoca | Romania | Completed |
| Centrul De Oncologie SF Nectarie S.R.L. Coordinator of this site? Confirm its status | Craiova | Romania | Completed |
| Sigmedical Services S.R.L. Coordinator of this site? Confirm its status | Suceava | Romania | Completed |
| Local Institution - 0004 Coordinator of this site? Confirm its status | Singapore | Singapore | Unknown status |
| Local Institution - 0001 Coordinator of this site? Confirm its status | Singapore | Singapore | Unknown status |
| Local Institution - 0041 Coordinator of this site? Confirm its status | Taichung | Taiwan | Unknown status |
| Local Institution - 0034 Coordinator of this site? Confirm its status | Tainan | Taiwan | Unknown status |
| Local Institution - 0031 Coordinator of this site? Confirm its status | Taipei | Taiwan | Unknown status |
| Local Institution - 0042 Coordinator of this site? Confirm its status | Taipei | Taiwan | Unknown status |
| Local Institution - 0032 Coordinator of this site? Confirm its status | Taoyuan | Taiwan | Unknown status |
| Local Institution - 0089 Coordinator of this site? Confirm its status | Ankara | Turkey (Türkiye) | Unknown status |
| Local Institution - 0090 Coordinator of this site? Confirm its status | Edirne | Turkey (Türkiye) | Unknown status |
| Local Institution - 0091 Coordinator of this site? Confirm its status | Kadiköy/Istanbul | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.