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NCT04567615CompletedPhase 2

A Study of Relatlimab in Combination With Nivolumab in Participants With Advanced Liver Cancer Who Have Never Been Treated With Immuno-oncology Therapy After Prior Treatment With Tyrosine Kinase Inhibitors

A Phase 2, Randomized, Open-label Study of Relatlimab in Combination With Nivolumab in Participants With Advanced Hepatocellular Carcinoma Who Are Naive to IO Therapy But Progressed on Tyrosine Kinase Inhibitors (RELATIVITY-073)

Source: ClinicalTrials.gov · Last updated 8 Jan 2026

Brief summary (registry, in English)

The purpose of this study is to evaluate the effectiveness and safety of relatlimab in combination with nivolumab in participants with advanced liver cancer who have never been treated with immuno-oncology therapy, after prior treatment with tyrosine kinase inhibitor therapy.

Status (registry)
Completed
Phase (registry)
Phase 2
Study type
Interventional
Enrollment
266 (actual)
First submitted
24 Sept 2020
Start date
4 Feb 2021
Primary completion date
31 Aug 2023
Lead sponsor
Bristol-Myers Squibb
NCT number
NCT04567615
EU CT number
2023-503519-13-00
EudraCT number
2018-003151-38

What you commit to

  • Study type: Interventional · Phase 2
  • Participants enrolled: 266
  • From 4 Feb 2021 to the primary completion date, 31 Aug 2023
  • 61 sites in 17 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Prior organ allograft or allogeneic bone marrow transplantation
  • Have received one or two lines of tyrosine kinase inhibitor therapies
  • Evidence of radiographic progression on or after the last line of tyrosine kinase inhibitor therapy
    • Other protocol-defined inclusion/exclusion criteria apply

Other illness

  • No uncontrolled or significant cardiovascular disease
  • No active known autoimmune disease

Other

  • Known fibrolamellar HCC, sarcomatoid HCC, combined hepatocellular cholangiocarcinoma

Who the study is looking for

  • Must have a diagnosis of hepatocellular carcinoma (HCC) based on histological confirmation
  • Must have advanced/metastatic HCC
  • Have to be immunotherapy treatment-naive in the advanced/metastatic setting
  • Must have at least one Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 measurable untreated lesion
  • Child-Pugh score of 5 or 6
  • Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1 for ECOG performance status scale

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (61)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Local Institution - 0019
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Buenos AiresArgentinaUnknown status
Local Institution - 0010
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Ciudad de Buenos AiresArgentinaUnknown status
Local Institution - 0017
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RosarioArgentinaUnknown status
Local Institution - 0063
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San Miguel de TucumánArgentinaUnknown status
Local Institution - 0016
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BarretosBrazilUnknown status
Local Institution - 0025
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Belo HorizonteBrazilUnknown status
Local Institution - 0060
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Porto AlegreBrazilUnknown status
Unidade de Pesquisa Clínica do Hospital da Clínicas de Ribeirão Preto-Clinical Oncology
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Ribeirão PretoBrazilUnknown status
Local Institution - 0015
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São PauloBrazilUnknown status
Local Institution - 0018
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SantiagoChileUnknown status
Local Institution - 0029
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SantiagoChileUnknown status
Local Institution - 0024
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TemucoChileUnknown status
Local Institution - 0114
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ChangshaChinaUnknown status
Local Institution - 0117
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HangzhouChinaUnknown status
Local Institution - 0113
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HarbinChinaUnknown status
Local Institution - 0107
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ShanghaiChinaUnknown status
Local Institution - 0108
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Xi'anChinaUnknown status
Local Institution - 0118
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Xi'anChinaUnknown status
Masaryk Memorial Cancer Institute
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Brno-StredCzechiaCompleted
Hospital Clinic de Barcelona
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BarcelonaSpainCompleted
Hospital Universitario Reina Sofia
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CórdobaSpainCompleted
Hospital Universitario Donostia
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DonostiaSpainCompleted
Hospital General Universitario Gregorio Marañón
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MadridSpainCompleted
Hospital Universitario 12 de Octubre
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MadridSpainCompleted
University Clinic of Navarra
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PamplonaSpainCompleted
Hopital Beaujon
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ClichyFranceCompleted
Centre Hospitalier Universitaire Grenoble Alpes
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Grenoble Cedex 9FranceCompleted
Hopital De La Croix-Rousse
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Lyon Cedex 04FranceCompleted
Centre Hospitalier Universitaire de Bordeaux
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PessacFranceCompleted
CHRU De Nancy
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Vandoeuvre Les NancyFranceCompleted
Local Institution - 0077
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HksarHong Kong SAR ChinaUnknown status
Local Institution - 0079
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ShatinHong Kong SAR ChinaUnknown status
Local Institution - 0075
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IshikawaJapanUnknown status
Local Institution - 0071
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KyotoJapanUnknown status
Local Institution - 0072
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MatsuyamaJapanUnknown status
Local Institution - 0045
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Ōsaka-sayamaJapanUnknown status
Local Institution - 0076
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YokohamaJapanUnknown status
Local Institution - 0054
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YokohamaJapanUnknown status
Local Institution - 0020
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Seongnam-siSouth KoreaUnknown status
Local Institution - 0011
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SeoulSouth KoreaUnknown status
Local Institution - 0043
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SeoulSouth KoreaUnknown status
Local Institution - 0100
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CuauhtémocMexicoUnknown status
Local Institution - 0106
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Oaxaca CityMexicoUnknown status
Local Institution - 0101
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San Luis Potosí CityMexicoUnknown status
Local Institution - 0003
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AucklandNew ZealandUnknown status
Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki W Krakowie
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CracowPolandCompleted
Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy
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WarsawPolandCompleted
Fundeni Clinical Institute
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BucharestRomaniaCompleted
Institute Of Oncology Prof. Dr. Ion Chiricuta Cluj-Napoca
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Cluj-NapocaRomaniaCompleted
Centrul De Oncologie SF Nectarie S.R.L.
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CraiovaRomaniaCompleted
Sigmedical Services S.R.L.
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SuceavaRomaniaCompleted
Local Institution - 0004
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SingaporeSingaporeUnknown status
Local Institution - 0001
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SingaporeSingaporeUnknown status
Local Institution - 0041
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TaichungTaiwanUnknown status
Local Institution - 0034
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TainanTaiwanUnknown status
Local Institution - 0031
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TaipeiTaiwanUnknown status
Local Institution - 0042
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TaipeiTaiwanUnknown status
Local Institution - 0032
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TaoyuanTaiwanUnknown status
Local Institution - 0089
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AnkaraTurkey (Türkiye)Unknown status
Local Institution - 0090
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EdirneTurkey (Türkiye)Unknown status
Local Institution - 0091
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Kadiköy/IstanbulTurkey (Türkiye)Unknown status

This page is information, not medical advice. Discuss any trial with your doctor.