NCT04570761Completed
Effects of Auditory Brain Stimulation by "Pink Noise" on Memory Capacities in Alzheimer's Disease: Proof of Concept Study
Source: ClinicalTrials.gov · Last updated 15 Jun 2026
Brief summary (registry, in English)
Alzheimer's disease (AD) is a neurodegenerative disorder affecting almost 6% of the world's population over the age of 65. This disease, in its most typical sporadic form, is characterized by an episodic memory impairment linked to a deficit in consolidation. Many studies indicate that sleep promotes this consolidation stage during the deep slow sleep stage by facilitating the transfer of information between the hippocampus and the neocortex. A method of acoustic brain stimulation at night by pink noises has been recently developed and has shown its effectiveness in strengthening memory consolidation in healthy volunteers. Actually, there is no study observing the effect of this new stimulation method on populations with neurodegenerative pathologies, in particular in AD for which this technique could potentially become a therapeutic option. The hypothesis is that of a strengthening of the memory consolidation capacities in subjects with AD as has been shown in healthy subjects.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 19 (actual)
- First submitted
- 8 Sept 2020
- Start date
- Mar 2021
- Primary completion date
- Mar 2024
- Lead sponsor
- University Hospital, Tours
- Diseases
- Alzheimer disease
- NCT number
- NCT04570761
What you commit to
- Study type: Interventional
- Participants enrolled: 19
- From Mar 2021 to the primary completion date, Mar 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Sleep disorders defined by a score\> 5 on the Pittsburg sleep quality index (PSQI)
Other
- A score\> 10 on the Epworth sleepiness index
Who the study is looking for
- Age\> 50 years at the inclusion
- Patient with regular sleep patterns
- Patient having given written consent
- Patient affiliated to a social security regimen
- Patient with a beginning Alzheimer's disease defined according to the criteria of the National Institute on Aging-Alzheimer's Association or carriers of a prodromal Alzheimer's disease defined according to the criteria of the International Working Group IWG-2; the diagnosis must be supported by brain imaging and a blood test carried out in routine care
- MMSE score ≥ 24
- Absence of neurodegenerative pathologies
- Matched in age (+/- 5 years) and in sex with a patient
- Non-inclusion criteria common to all participants:
- Psychiatric pathologies (except depression or anxiety disorders stabilized for more than 3 months)
- History of pathology which may have consequences on cognitive functioning and / or sleep: brain tumor, constituted stroke, epilepsy, head trauma (with clinical or parenchymal sequelae objectified on brain imagery), brain surgery
- Any significant comorbidity likely to constitute a confounding factor according to the clinician
- Psychotropic treatments introduced or modified \<3 months before inclusion
- Hypnotic and / or sedative treatments
- Chronic consumption of alcohol or drugs
- Legal incapacity and / or other circumstance rendering the patient unable to understand the nature, objective or consequences of the study
- Major under guardianship or curatorship
- Patient not French-speaking by birth or illiterate
Age in the registry: 50 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospital of Tours Coordinator of this site? Confirm its status | Tours | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.