NCT04576182Recruiting
Supportive-Expressive and Emotion-Focused Treatment for Depression
Investigating Mechanisms of Change in Supportive-Expressive vs. Emotion-Focused Treatment of Depression Using a Personalized Treatment Approach: The Case of the Theories of Weakness vs. Strength
Source: ClinicalTrials.gov · Last updated 7 May 2026
Brief summary (registry, in English)
This study will explore the mechanisms of change that are activated when individuals receive a treatment that targets their weakness and the mechanisms activated when the treatment capitalize on their strength. Patients will be assigned to one of two types of psychotherapies in treating people with a major depression disorder, expressive-supportive vs. emotion-focused treatment. Their ability to benefit from treatment based on their pre-treatment levels of insight and emotional processing will be examined. This is a four-month protocol, with a 2 year follow up period.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 124 (estimated)
- First submitted
- 26 Sept 2020
- Start date
- 29 Nov 2020
- Primary completion date
- 30 Nov 2026
- Lead sponsor
- University of Haifa
- Diseases
- Depression
- NCT number
- NCT04576182
What you commit to
- Study type: Interventional
- Planned participants: 124
- From 29 Nov 2020 to the primary completion date, 30 Nov 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- current substance abuse disorders
- current or past schizophrenia or psychosis, bipolar disorder, or severe eating disorder requiring medical monitoring
- history of organic mental disease
Other
- Current risk of suicide or self-harm
- currently in psychotherapy
Who the study is looking for
- Meeting major depressive disorder diagnostic criteria using the structured clinical interviews for Diagnostic and Statistical Manual of Mental Disorders-5 and scoring more than 14 on the 17-item Hamilton rating scale for depression at two evaluations (one week apart) (Hamilton, 1967).
- If on medication, patients' dosage must be stable for at least three months prior to entering the study, and they must be willing to maintain stable dosage for the duration of treatment
- Age between 18 and 65
- Hebrew language fluency
- Provision of written informed consent.
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Haifa Coordinator of this site? Confirm its status | Haifa | Israel | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.