NCT04581980Completed
Effects of Obesity and Intensity of Exercise on Ghrelin Levels
Modulation of Ghrelin Release by Exercise Intensity: The Role of Obesity and Prediabetes Status
Source: ClinicalTrials.gov · Last updated 17 Sept 2025
Brief summary (registry, in English)
This study is investigating the effect of different intensities of exercise on levels of the hormone, ghrelin. In addition, we will be examining the relationship between any exercise induced changes in ghrelin and insulin sensitivity, obesity, and vascular function.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 40 (actual)
- First submitted
- 1 Oct 2020
- Start date
- 14 Oct 2020
- Primary completion date
- 16 Apr 2025
- Lead sponsor
- University of Virginia
- Diseases
- Obesity
- NCT number
- NCT04581980
What you commit to
- Study type: Interventional
- Participants enrolled: 40
- From 14 Oct 2020 to the primary completion date, 16 Apr 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Smoking (must have quit at least 6 months prior)
- The following medications (due to their effect on insulin sensitivity ,endothelial function and/or ghrelin secretion): Synthetic growth hormone, metformin, synthetic insulin, sulfonylureas, meglitinides, Thiazolidinediones, DPP-4 inhibitors, GLP-1 receptor agonists, SGLT2 inhibitors , biguanides, alpha-glucosidase inhibitors, phosphodiesterase inhibitors, beta-blockers, alpha-blockers, ACE-inhibitors, ARB's, fibrates, glucocorticoids, olanzapine
Other illness
- History of diabetes, gastrointestinal disease, or endocrine disorder
Other
- Disordered eating
- Females currently pregnant or undergoing fertility treatments
Who the study is looking for
- 18-55 years of age
- BMI between 18-40 kg/m2
- Untrained (reports less than 2 days/week of exercise)
- Weight stable (no significant loss/gain of more than 3kg in the past 3 months)
- Females must be premenopausal and report normal menstrual cycles
Age in the registry: 18 years to 55 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Virginia Coordinator of this site? Confirm its status | Charlottesville | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.