NCT04583046Completed
Effects of Iloprost on Pulmonary Oxygenation in Obese Patients During One-lung Ventilation
Source: ClinicalTrials.gov · Last updated 1 Dec 2025
Brief summary (registry, in English)
One lung ventilation (OLV) is essential during thoracic surgery. During OLV, intrapulmonary shunt can be increased resulting hypoxemia. Although OLV technique had been advanced so far, hypoxemia during OLV reaches about 10% in spite of inspired oxygen fraction 100%. Iloprost is a prostaglandin analogue used for pulmonary hypertension, which can decrease pulmonary artery resistance by selectively dilating pulmonary artery. In this prospective, randomized, double blind study, the investigator is planning to investigate the effects of iloprost on respiratory physiology (intrapulmonary shunt, deadspace, oxygenation, etc) in obese patients.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 78 (actual)
- First submitted
- 17 Sept 2020
- Start date
- 2 Nov 2020
- Primary completion date
- 26 Sept 2025
- Lead sponsor
- Yonsei University
- Diseases
- Obesity, Lung cancer
- NCT number
- NCT04583046
What you commit to
- Study type: Interventional
- Participants enrolled: 78
- From 2 Nov 2020 to the primary completion date, 26 Sept 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Severe obstructive lung disease and/or restrictive lung disease patients
- patients with end-organ diseases (i.e. heart failure, respiratory failure, hepatic failure, renal failure)
- arrhythmia
- pulmonary edema or pulmonary arterial hypertension
- cerebrovascular disease
- unstable angina or myocardial infarction within 6 months
- patients with allergic reaction at iloprost
Other
- American Society of Anaesthesiologists(ASA) physical status classification IV or more
- NYHA class III\~IV
- pregnant women
Who the study is looking for
- scheduled for VATS lobectomy
- 40 \< age \< 80
- American Society of Anaesthesiologists(ASA) physical status classification I\~III
- BMI \> 30 kg /m2
Age in the registry: 40 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Severance hospital Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.