NCT04589624RecruitingPhase 1
An Investigational Scan (hpMRI) for Monitoring Treatment Response in Patients With Thyroid Cancer and Other Malignancies of the Head and Neck Undergoing Radiation Therapy and/or Systemic Therapy
Pilot Study of Metabolic Guidance for Therapy in Patients With Thyroid Cancer and Other Malignancies of the Head and Neck
Source: ClinicalTrials.gov · Last updated 22 May 2026
Brief summary (registry, in English)
This trial investigates whether hyperpolarized magnetic resonance imaging (hpMRI) can predict treatment response in patients with thyroid cancer and other malignancies of the head and neck undergoing radiation therapy and/or receiving systemic therapy before surgery. An hpMRI is like a standard MRI but involves the use of an imaging contrast agent called hyperpolarized 13-C-pyruvate. Diagnostic procedures, such as hpMRI, may predict a patient's response to treatment and may help plan the best treatment.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 42 (estimated)
- First submitted
- 20 Sept 2020
- Start date
- 12 Aug 2020
- Primary completion date
- 31 May 2027
- Lead sponsor
- M.D. Anderson Cancer Center
- Diseases
- Thyroid cancer
- NCT number
- NCT04589624
What you commit to
- Study type: Interventional · Phase 1
- Planned participants: 42
- From 12 Aug 2020 to the primary completion date, 31 May 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Have electrically, magnetically or mechanically activated implants that would preclude magnetic resonance imaging (MRI)
Other illness
- Have a history of severe claustrophobia
- Have a history of cardiac arrhythmia
- Have an allergy to Gadavist intravenous contrast
Lab values
- Estimated glomerular filtration rate (eGFR) \< 30
Other
- If female, be pregnant or breast feeding at time of consent
Who the study is looking for
- Be willing and able to provide informed consent
- Be informed of the investigational nature of this study
- Be diagnosed with thyroid cancer and other malignancies of the head and neck with intent for treatment
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| M D Anderson Cancer Center Coordinator of this site? Confirm its status | Houston | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.