NCT04592003Recruiting
French Colorectal ESD Cohort in Experts Centers
Source: ClinicalTrials.gov · Last updated 15 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Initially developed in Japan for the treatment of endemic superficial gastric cancers, endoscopic submucosal dissection (ESD) allows resection of pre-neoplastic and neoplastic lesions of the digestive tract into a single fragment. It allows a perfect pathological analysis, and decreases the rate of recurrence of the adenoma to less than 2%. However, this procedure, which is technically more challenging, is also more risky (perforation rate at 4% vs. 1% for WF-EMR) and longer. Submucosal dissection is also more expensive in terms of equipment, but this difference can be offset by the cost of the high number of iterative colonoscopies required in patients who have had endoscopic resection by WF-EMR. Scientific debate is agitating the Western world1,2 and Japanese experts do not perform WF-EMR anymore, whereas no comparative prospective study has compared these two procedures. A lot of centers in France performed colorectal ESD even for benign lesions and nationwide data about safety and efficiency is required to confirm the place of ESD for treatment of large superficial colorectal lesions. The aim of this French multicenter cohort is to analyze the results of colorectal submucosal dissection on a large scale.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 1200 (estimated)
- First submitted
- 8 Oct 2020
- Start date
- 1 Jan 2020
- Primary completion date
- 1 Jan 2026
- Lead sponsor
- University Hospital, Limoges
- Diseases
- Colorectal cancer
- NCT number
- NCT04592003
What you commit to
- Study type: Observational
- Planned participants: 1200
- From 1 Jan 2020 to the primary completion date, 1 Jan 2026
- 25 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Opposition notified in the context of a non-opposition form after reading the information notice
Who the study is looking for
- All patients addressed for a colorectal ESD
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (25)
Sites in registry order. Pick your city on the disease page to sort them by distance.
Related publications
- Outcomes of perforation after colorectal endoscopic submucosal dissection in a large prospective multicenter cohort.Endoscopy · 2026 · PMID 42119692
This page is information, not medical advice. Discuss any trial with your doctor.