NCT04595006Active, not recruiting
Brown Fat Activation and Browning Efficiency Augmented by Chronic Cold and Nutraceuticals for Brown Adipose Tissue-mediated Effect Against Metabolic Syndrome (BEACON BEAMS Study)
Source: ClinicalTrials.gov · Last updated 6 May 2025
Brief summary (registry, in English)
Our body fat (adipose tissue) is largely made up of white adipose tissue (WAT) that stores surplus energy as white fat depots. In addition, adult humans have another type of fat similar to the brown fat in babies that burns up fat to generate heat for maintenance of body temperature during cold exposure. Adults have much lesser amounts of such brown adipose tissue (BAT), most of which are located within the sides of the neck and under the skin above the collar bones as well as along the sides of the spine. BAT consists of both classical brown fat identical to that found in babies as well as beige fat (composed of brown-in-white or 'brite' fat cells) found mainly in adults. Both types of BAT burn fat upon activation by various stimuli such as cold or by substances like curcumin found in turmeric ginger rhizome root. This study is carried out to find out the effects of cold stimulation and/or a known BAT-activating nutraceutical among those overweight/obese people suffering from metabolic syndrome.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 14 Oct 2020
- Start date
- 15 Jan 2021
- Primary completion date
- 31 Oct 2023
- Lead sponsor
- Institute for Human Development and Potential (IHDP), Singapore
- Diseases
- Obesity
- NCT number
- NCT04595006
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 15 Jan 2021 to the primary completion date, 31 Oct 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Have major medical or surgical event requiring hospitalization within the preceding 3 months
- Have taken antibiotics for 3 months before the study period
- Having active Tuberculosis (TB) or currently receiving treatment for TB
- Have any known Chronic Infection or known to suffer from or have previously suffered from or is a carrier of Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV)
- Enrolled in a concurrent research study judged not to be scientifically or medically compatible with the study of the CNRC
Other illness
- Have major chronic disease such as heart disease or cancer
- Have any known food allergy (eg. anaphylaxis to peanuts)
- Have any history of severe vasovagal syncope (blackouts or near faints) following blood draws
- History of surgery with metallic clips, staples or stents
- Presence of cardiac pacemaker or other foreign body in any part of the body
- History of claustrophobia particularly in a MRI scanner
Lab values
- Have known glucose-6-phosphate dehydrogenase (G6PD) deficiency
- Take insulin or drugs known to affect glucose metabolism
Other
- Are pregnant or contemplating pregnancy (for female subjects)
- Partake in sports at the competitive and/or endurance levels
- Intentionally restrict food intake
- Are a smoker
- Are an overnight shift worker
- Are a member of the research team or their immediate family members. Immediate family member is defined as a spouse, parent, child, or sibling, whether biological or legally adopted.
- Have poor veins impeding venous access
Who the study is looking for
- Male or Female
- Chinese, Malay or Indian ethnicity
- Age between 21 to 50 years
- Able to give informed consent
- Body mass index (BMI) between 23 to 32 kg/m2
- Thyroid function test must be within the normal ranges
- Willing to avail yourself for the whole study and follow study procedures
- EITHER deemed to have pre-metabolic syndrome when waist circumference is \> 90 cm in men or \> 80 cm in women, with none or up to one of the following condition:
- Triglyceride level ≥ 1.7 mmol/L
- HDL cholesterol ≤ 1.0 mmol/L in men, and ≤ 1.3 mmol/L in women
- Blood pressure ≥ 130/85 mmHg
- Fasting blood glucose of ≥ 6.1 mmol/L
- OR deemed to have metabolic syndrome when three or more of the following conditions are present:
- Waist circumference \> 90 cm in men and \> 80 cm in women
- Triglyceride level ≥ 1.7 mmol/L
- HDL cholesterol ≤ 1.0 mmol/L in men, and ≤ 1.3 mmol/L in women
- Blood pressure ≥ 130/85 mmHg
- Fasting blood glucose of ≥ 6.1 mmol/L
Age in the registry: 21 years to 50 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Singapore Institute of Clinical Sciences Coordinator of this site? Confirm its status | Singapore | Singapore | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.