NCT04599309Active, not recruiting
Real-time Detection of ctDNA and/or HPV DNA in High-risk Locally-advanced Head and Neck Squamous Cell Carcinoma
Real-time Detection of ctDNA and/or HPV DNA in High-risk Locally-advanced Head and Neck Squamous Cell Carcinoma (LA-HNSCC): The Pre-MERIDIAN (Molecular Residual Disease Interception in High-risk LA-HNSCC) Study.
Source: ClinicalTrials.gov · Last updated 10 Jun 2026
Brief summary (registry, in English)
This research study will include patients with high risk locally advanced head and neck squamous cell carcinoma (LA-HNSCC) of the oral cavity, oropharynx, hypopharynx or larynx and patients that are starting on standard definitive treatment. Patients with both stage III HPV positive and stage III HPV negative will be included. In this study, we aim to evaluate feasibility of ctDNA and/or HPV DNA detection in real time in high-risk LA-HNSCC.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 35 (actual)
- First submitted
- 18 Oct 2020
- Start date
- 15 Oct 2020
- Primary completion date
- 31 Mar 2023
- Lead sponsor
- University Health Network, Toronto
- Diseases
- Head and neck cancer
- NCT number
- NCT04599309
What you commit to
- Study type: Observational
- Participants enrolled: 35
- From 15 Oct 2020 to the primary completion date, 31 Mar 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Early stage HNSCC (I and II)
- Distant metastatic HNSCC
Who the study is looking for
- Histologically or cytological confirmed LA-HNSCC of the oral cavity, oropharynx, hypopharynx, or larynx.
- Stage III HPV Positive or Stage III-IV HPV negative.
- Availability of tumor sample
- Patients who are candidates for standard definitive treatment defined as:
- Surgery followed by radiotherapy +/- chemotherapy OR
- Definite radiotherapy OR
- Definite chemoradiotherapy.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Princess Margaret Cancer Centre Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.