NCT04599621Recruiting

Unstable Angina Pectoris in Comorbidity With Anxiety-depressive Syndrome

Immunological Features of Unstable Angina Pectoris in Comorbidity With Anxiety-depressive Syndrome

Source: ClinicalTrials.gov · Last updated 23 Oct 2020 · Not updated for over 12 months - ask the site whether it is still open

Brief summary (registry, in English)

Introduction: Today it is necessary to emphasize that coronary heart disease is often associated with anxiety disorders. Research over the years has shown several and sometimes surprising links between coronary heart disease and mental illness, and has even suggested that both of these phenomena may actually cause each other. However, the exact nature of these links has not yet been clearly established. Methods: The study included 202 patients with coronary artery disease, of whom 42 patients were with stable angina pectoris, they participated as a control group, and 160 patients with unstable angina pectoris, who made up the main group. Among them there are 102 women and 100 men between the ages of 30 and 88. The average age was 63.75 ± 11.37 years. All study participants had blood in the morning on fasting after 8-12 hours of fasting from the cubital vein. Determination of the level of cytokines TNF-α, IL-1β, IL-4 and IL-10 in blood serum by enzyme-linked immunosorbent assay (ELISA). All participants in the study had blood drawn in the morning on fasting after 8-12 hours of fasting from the cubital vein. The level of uric acid was determined on the CYAN Start apparatus using a unified method. When examining patients with unstable angina pectoris were used: hospital anxiety and depression scale \[Kozlova S.N. 2013\]. And also the Spielberger-Khanin scale \[Psychiatry - Hoffman A.G. 2010\], developed by Spielberger Ch.D. and adapted by Yu.L. Khanin. to assess cognitive functions \[Psychiatry - Gofman A.G. 2010\].

Status (registry): Recruiting
Study type: Observational
Enrollment: 3 (estimated)
First submitted: 6 Oct 2020
Start date: 5 Nov 2018
Primary completion date: 25 Dec 2025
Lead sponsor: Samarkand State Medical Institute
Diseases: Coronary artery disease
NCT number: NCT04599621

What you commit to

Study type: Observational
Planned participants: 3
From 5 Nov 2018 to the primary completion date, 25 Dec 2025
1 site in 1 country
Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

The presence of concomitant acute diseases or chronic diseases in the acute stage.
- Throughout the study, all patients were assigned the right to voluntarily withdraw from the study at their own request, notifying the researcher in writing or orally.

Other illness

Severe and unstable condition of the patient, making it difficult to conduct a questionnaire (for ethical reasons);
History of acute or chronic psychosis;

Other

The patient's refusal to participate in the study;
Pregnancy and lactation;
Acute violation of cerebral circulation;

Who the study is looking for

the presence of an established diagnosis in patients with coronary artery disease
unstable angina pectoris (NS). When making a diagnosis, the recommendations of ESH / ESC (2015) and RCO / WHO (2014) were used.
stable exertional angina (SSN) I-III FC. When making the diagnosis, the IHD classification was used, adopted at the IV Congress of Cardiologists of the Republic of Uzbekistan (2000), as well as in accordance with the recommendations of ESH / ESC (2019) and RCO / WHO (2017)

Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

Site	City	Country	Site status
Zarina Coordinator of this site? Confirm its status	Samarkand	Uzbekistan	Recruiting

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