Testosterone Treatment for Erectile Dysfunction and Multiple Sclerosis

Prior treatment

• Males who have been on sex hormone treatment including androgens, estrogens, or anti-estrogens for hypogonadism or other medical condition during the 12 months prior to study.
• Males who have taken dehydroepiandrosterone (DHEA) during the 3 months prior to study.
• Patients who are receiving or have received experimental therapies in the six months preceding enrollment.

Other illness

• Patients who are taking anticoagulants or have thrombosis, serious cardiac, pulmonary, renal, gastrointestinal, hepatic, immunologic, infectious, neoplastic (with particular focus on patients with known or suspected estrogen or testosterone-dependent tumors), urologic disease especially prostatic hypertrophy/nodules and testicular mass, or insulin-dependent diabetes.
• Patients with an abnormal prostate as evidenced by known history of prostatic disease, symptoms suggestive of prostatic disease or elevated levels of prostatic specific antigen (PSA 4 ng/ml or higher) measured within the last 12 months.
• Patients with major psychiatric illness
• Patients with a history of drug abuse within the past five years.
• Patients with generalized skin disease that may affect absorption of testosterone (e.g. psoriasis) or a known skin intolerance to alcohol.
• Patients with history of pituitary disease.
• Patients who have clinical evidence of Lyme disease.

Lab values

• Patients with a cholesterol level greater than 300 mg/dl.
• Patients who have history of positive titers to Human Immunodeficiency Virus (HIV)1 and 2; HTLV1; or Venereal Disease Research Laboratory (VDRL).

Other

• Males unable to fulfill the above criteria and all female patients.
• Patients with history or complaint of testicular mass.
• Patients with hematocrit greater than 50%
• Patients with active alcoholism.
• Patients with BMI ≥ 35
• Males who are trying to get their partner pregnant.
• Patients on Finasteride
• Patients who are mentally or emotionally incompetent in the opinion of the examining neurologist or unable to give informed consent, or to understand and comply with the study protocol.
• Any other contraindications according to the manufacturer's exclusion criteria.

• Males, age 18 years and older, with a definite diagnosis of multiple sclerosis.
• Low testosterone (<300 ng/dl) on two successive blood draws before 9:00 am
• Not in an intercurrent relapse.
• Sexually active.
• Have subjective complaints about erectile function and libido.
• Must be willing and able to get labs drawn, complete questionnaires (BDI, MFIS, MSNQ, SDMT, MSQOL, ADAM, AUASS, SHIM, MSHQ, ICIQ, UDI, IIQ, MPQ) and commit to site visits schedule.