NCT04603014Active, not recruitingPhase 2
Interdialytic Peritoneal UltraFiltration in HemoDialysis Patients
Initial Feasibility Pilot Study of Interdialytic Peritoneal Ultrafiltration to Manage Volume Status in Hemodialysis Patients
Source: ClinicalTrials.gov · Last updated 4 May 2026
Brief summary (registry, in English)
Sodium accumulates in the tissues of patients with kidney disease and impairs survival. Three-times weekly, standard hemodialysis alone cannot remove excess sodium efficiently. A sample of 10 chronic hemodialysis patients will undergo a 5-week, pilot, interventional study to test the efficacy of additional sodium removal in-between hemodialysis sessions, twice per week, for three weeks. Tissue sodium removal will be achieved with peritoneal dialysis after the surgical insertion of a peritoneal dialysis catheter. Tissue sodium removal will be assessed at the beginning and at the end of the study with sodium magnetic resonance imaging of a peripheral limb (leg). Patients will also undergo monitoring for symptoms and blood pressure throughout the study to assess the safety of this procedure.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 10 (estimated)
- First submitted
- 13 Oct 2020
- Start date
- 1 Jan 2021
- Primary completion date
- 30 Dec 2026
- Lead sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
- Diseases
- Chronic kidney disease
- NCT number
- NCT04603014
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 10
- From 1 Jan 2021 to the primary completion date, 30 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Uncontrolled diabetes mellitus
- Active infections
Lab values
- Pre-study serum sodium \< 130 mmol/L
Other
- Contraindications to peritoneal dialysis
- Contraindications to MRI
- Non-compliance to hemodialysis prescription
Who the study is looking for
- At least one of the following:
- Average per-session interdialytic weight gain ≥ 4.0 % of their dry weight in the last month;
- Inability to consistently achieve dry weight with the current treatment schedule;
- Need for additional HD treatments to achieve prescribed dry weight.
- Weekly HD sessions - up to three times/week
- Age ≥18 years
- Willing and able to give informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| London Health Sciences Centre Coordinator of this site? Confirm its status | London | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.