NCT04608604Completed
Mobility in Atypical Parkinsonism: a Trial of Physiotherapy
Mobility in Atypical Parkinsonism: a Randomized Trial of Physiotherapy
Source: ClinicalTrials.gov · Last updated 16 May 2025
Brief summary (registry, in English)
Patients with atypical parkinsonism often show gait and mobility impairment manifesting in early disease stages. In order to maintain mobility and physical autonomy as long as possible for these patients, we will examine the effect of two types of physiotherapy in patients with multiple system atrophy (MSA), progressive supranuclear gaze palsy (PSP) and idiopathic Parkinson's disease (IPD). The study is divided into an ambulant daily in-patient physiotherapy phase, followed by a home-based training phase. At the beginning and the end of the study, the patients daily activity will be recorded for one week using Physical Activity Monitoring (PAM) sensors. The aim of this double-blind, randomized-controlled study is to determine effective physiotherapy in patients with atypical parkinsonian syndromes in order to maintain mobility for as long as possible.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 180 (actual)
- First submitted
- 19 Oct 2020
- Start date
- 1 Feb 2021
- Primary completion date
- 8 Jan 2025
- Lead sponsor
- Victoria Sidoroff
- Diseases
- Parkinson disease
- NCT number
- NCT04608604
What you commit to
- Study type: Interventional
- Participants enrolled: 180
- From 1 Feb 2021 to the primary completion date, 8 Jan 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Change of antiparkinsonian and anti-OH medication 4 weeks prior to the interventional trial.
Other illness
- Secondary cause of autonomic failure or parkinsonism (e.g. diabetic autonomic neuropathy, bladder surgery, drug-induced or vascular parkinsonism, etc.)
- Dementia according to DSM-V.
Other
- Co-morbidities that influence the clinical presentation of parkinsonian symptoms (as judged by the enrolling investigator).
- Participation in other clinical trials that might influence the impact of the trial intervention (as judged by the enrolling investigator)
- H\&Y Staging score greater than or equal to 4
Who the study is looking for
- The subject is willing and able to give written informed consent
- The patient is able to tolerate all study visits including daily physiotherapy and home training.
- Patients similar with regard to age and sex with probable/possible MSA-P according to rev. Gilman criteria OR probable/possible PSP-RS according to MDS-PSP criteria OR PD according to MDS-PD criteria.
- Stable antiparkinsonian and Anti-OH medication 4 weeks prior to study entry.
Age in the registry: 30 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Medical University Innsbruck Coordinator of this site? Confirm its status | Innsbruck | Austria | Unknown status |
Related publications
- Moving beyond the hospital: in-depth characterization of daily-life mobility in patients with atypical Parkinsonian disorders.NPJ Parkinsons Dis · 2026 · PMID 41526364
This page is information, not medical advice. Discuss any trial with your doctor.