NCT04610710Terminated
Impact of Operation on Fertility for Women With Severe Endometriosis
Comparing Impact of Operation and Fertility Treatment on Fertility for Women With Deep Infiltrating Endometriosis: A Multicenter Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 10 Mar 2026
Reason given: Enrolment of study participants was too challenging and long-drawn.
Brief summary (registry, in English)
The EFFORT study compares the impact on fertility of operation or fertility treatment (IVF, in vitro fertilization) in a multicenter randomized controlled trial. The study population consists of women with colorectal deep infiltrating endometriosis and a pregnancy intention. These women will be randomized to either of the two treatment groups: Group A = Operation or Group B = fertility treatment (IVF). Group A will be further divided postoperatively into spontaneous conception or IVF depending on the Endometriosis Fertility Index score.
- Status (registry)
- Terminated
- Study type
- Interventional
- Enrollment
- 38 (actual)
- First submitted
- 22 Oct 2020
- Start date
- 25 Nov 2020
- Primary completion date
- 1 Mar 2026
- Lead sponsor
- Horsens Hospital
- Diseases
- Endometriosis
- NCT number
- NCT04610710
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Contraindication for IVF (untreated uterine factor infertility, untreated/maltreated systemic or malignant disease, oocyte aspiration severely riskful (e.g. severe abdominal adhesions)
Other
- Endometriosis involving the ureter unilaterally or bilaterally (randomization unethical)
- BMI above 32
- No wish for randomization
Who the study is looking for
- Rectosigmoid endometriosis and wish for surgery
- Pregnancy intention for at least 6 months
- AMH above 5 pmol/ml
- Maximum of 2 previous IVF treatments
- Male partner
Age in the registry: 18 years to 38 years · Sex: Female · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Aarhus University Hospital | Aarhus N | Denmark | Unknown status |
| Horsens Regional Hospital | Horsens | Denmark | Unknown status |
| The Endometriosis Center, Clinique Tivoli-Ducos | Bordeaux | France | Unknown status |
Related publications
- EFFORT study: Surgery vs assisted reproductive technology among women with deep endometriosis - A multicenter randomized controlled trial.Eur J Obstet Gynecol Reprod Biol · 2026 · PMID 42617331
This page is information, not medical advice. Discuss any trial with your doctor.