Blood Pressure Reduction in Patients With Asymptomatic Aortic VALVE Stenosis

Prior treatment

• Participation in other randomized drug study (device studies accepted)
• Known or suspected ischemic heart disease (coronary angiography with \>70% stenosis in a major epicardial vessel, symptoms or signs of myocardial ischemia, e.g. angina pectoris, wall motion abnormalities). Patients who have previously undergone complete revascularization of major coronary arteries due to angina pectoris are eligible for inclusion.

Other illness

• Suspicion of secondary hypertension
• Significant coronary obstructive lesions detected by baseline Cardiac CT that requires a revascularisation procedure.
• Other disease, comorbidity or treatment making the subject unsuitable for study participation as judged by the investigator

Lab values

• eGFR \< 30 ml/min or end-stage renal disease

Other

• Symptoms due to AS
• Symptomatic orthostatic hypotension and/or one minute standing SBP \< 110 mmHg (16).
• Moderat to severe aortic valve regurgitation e.g. vena contracta \> 5 mm, assessed by echocardiography)

• Aortic valve peak velocity (Vmax) of 3.0-5.0 m/s and/or aortic valve area (AVA) ≤ 1.2 cm2
• Blood pressure: SBP \>= 127 mmHg measured by BP-TRU
• LVEF ≥ 50%
• Age \> 18 years
• Safe birth control management (intrauterine devices or hormonal contraceptives (contraceptive pills, implants, transdermal patches, hormonal vaginal devices or injections with prolonged release)) for women of childbearing potential.
• Negative urine-HCG for women of childbearing potential
• Ability to understand the written patient information and to give informed consent.