NCT04625049Enrolling by invitation

Does Microglial Activation Promote Lesion Growth and Progression Among Multiple Sclerosis Patients

Source: ClinicalTrials.gov · Last updated 22 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open

Brief summary (registry, in English)

The purpose of this study is to assess whether increased microglial activation (measured using TSPO-PET) at lesion rim is associated with more rapid lesion growth during 10 year follow up.

Status (registry): Enrolling by invitation
Study type: Observational
Enrollment: 100 (estimated)
First submitted: 5 Nov 2020
Start date: 1 Apr 2021
Primary completion date: Nov 2030
Lead sponsor: Turku University Hospital
Diseases: Multiple sclerosis
NCT number: NCT04625049

What you commit to

Study type: Observational
Planned participants: 100
From 1 Apr 2021 to the primary completion date, Nov 2030
1 site in 1 country
Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

Patients with other neurodegenerative disease than MS
Patients with claustrophobia, or a history of moderate to severe anxiety disorder or panic attacks (which could potentially lead to preterm termination of the imaging)

Other

Contraindication to MR scan investigations

Who the study is looking for

Participation to a previous PET imaging study of Airas group
MS diagnosis

Age in the registry: 30 years to 80 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

Site	City	Country	Site status
Turku PET Centre Coordinator of this site? Confirm its status	Turku	Finland	Unknown status

This page is information, not medical advice. Discuss any trial with your doctor.