NCT04628767RecruitingPhase 2/3
Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer
A Phase II/III Trial of Durvalumab and Chemotherapy for Patients With High Grade Upper Tract Urothelial Cancer Prior to Nephroureterectomy
Source: ClinicalTrials.gov · Last updated 30 Oct 2026
Brief summary (registry, in English)
This phase II/III trial compares the effect of adding durvalumab to chemotherapy versus chemotherapy alone before surgery in treating patients with upper urinary tract cancer. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as methotrexate, vinblastine, doxorubicin, cisplatin, and gemcitabine work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Durvalumab in combination with chemotherapy before surgery may enhance the shrinking of the tumor compared to chemotherapy alone.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2/3
- Study type
- Interventional
- Enrollment
- 131 (estimated)
- First submitted
- 13 Nov 2020
- Start date
- 12 Nov 2021
- Primary completion date
- 30 Sept 2027
- Lead sponsor
- National Cancer Institute (NCI)
- Diseases
- Bladder cancer
- NCT number
- NCT04628767
What you commit to
- Study type: Interventional · Phase 2/3
- Planned participants: 131
- From 12 Nov 2021 to the primary completion date, 30 Sept 2027
- 258 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Who the study is looking for
- STEP 1 REGISTRATION AND RANDOMIZATION
- Patients must be \>= 18 years of age
- Patient must have the ability to understand and the willingness to sign a written informed consent document. Patients with impaired decision-making capacity (IDMC) who have a legally authorized representative (LAR) or caregiver and/or family member available will also be considered eligible
- Patient must have a diagnosis of high grade upper tract urothelial carcinoma expected within 14 weeks (98 days) prior to registration/randomization with one of the following:
- Biopsy (gold standard, preferred) and either upper urinary tract mass on cross-sectional imaging or tumor directly visualized during upper urinary tract endoscopy
- High grade cytology and clinically estimated invasive upper urinary tract mass on cross-sectional imaging (e.g., including presence of tumor-related hydronephrosis) or tumor directly visualized during upper urinary tract endoscopy
- NOTE: Universal histologic testing of UTUC with additional studies, such as immunohistochemistry and/or microsatellite instability, is strongly recommended to identify patients with high probability of Lynch-related or other germline mutation related cancers whom clinicians should refer for genetic counseling and germline testing (this is not required for eligibility)
- Due to the anatomy of upper urinary tract and lack of muscularis propria, pathologic evidence of cT2 on biopsy is usually not possible
- Patients must not have any component of small cell/neuroendocrine carcinoma. Other histologic subtypes (variants) are permitted provided the half or predominant (\>= 50%) subtype is conventional urothelial carcinoma
- Leukocytes \>= 3,000/mcL (obtained =\< 14 days prior to registration/randomization)
- Platelets \>= 100,000/mcL (obtained =\< 14 days prior to registration/randomization)
- Total bilirubin =\< 1.2 mg/dL (or ≤ 2 mg/dL for patients with Gilbert's disease)
- Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase \[SGOT\]) and alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \[SGPT\]) =\< 2 x institutional ULN (obtained =\< 14 days prior to registration/randomization)
- Hemoglobin (Hgb) \>= 9 g/dL (obtained =\< 14 days prior to registration/randomization)
- NOTE: Packed red blood transfusion is allowed to achieve this parameter as per treating investigator
- Patients must not be pregnant or breast-feeding due to the potential harm to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used. All patients of childbearing potential must have a blood test or urine study within 14 days prior to registration to rule out pregnancy. A patient of childbearing potential is defined as any patient, regardless of whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
- Patients of childbearing potential and sexually active patients must not expect to conceive or father children, either by using accepted and effective method(s) of contraception or by abstaining from sexual intercourse from the time of registration, while on study treatment and for at least 6 months after the last dose of protocol treatment
- Patients must have no evidence of metastatic disease or clinically enlarged regional lymph nodes (\>= 1.5 cm short axis) on imaging required within 28 days prior to registration (Non-regional findings \>=1.5 cm short axis that in the opinion of the investigator are not concerning for involvement based on radiographic characteristics, chronicity, avidity on positron emission tomography (PET) scan or other imaging or other criteria can be eligible based on investigator discretion).
- NOTE: Patients with elevated alkaline phosphatase, calcium or suspicious bone pain/tenderness can also undergo baseline bone scan to evaluate for bone metastasis at the discretion of local provider.
- Patient must meet below criteria for prior/current malignancy history:
- Non-urothelial cancer malignancy history:
- Patient must not have another active (or within two years) second malignancy other than resected non-melanoma skin cancers, resected in situ breast, cervical or other in situ carcinoma, and either clinically insignificant per the investigator (e.g. =\< Gleason 3+4) on active surveillance (or watchful waiting) or previously treated prostate cancer with no rising prostate specific antigen (PSA) and no plan to treat
- NOTE: Patients with prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial.
- Urothelial cancer malignancy history:
- Patient may have a history of resectable urothelial cancer as long as patients meet one of the following:
- T0, Ta or Tis at any time
- T1-4a N0 and no evidence of disease (NED) for more than 2 years from the latest therapy \[e.g., radical surgery, transurethral resection of bladder tumor (TURBT), radiation, chemotherapy (neoadjuvant or adjuvant, or with radiation)\]. Prior systemic immune checkpoint inhibitor is not allowed.
- Patient with history of \>= pT4b, N+, and/or M1 UC is not eligible.
- NOTE: Patients in whom concomitant or prior bladder/urethra predominant (\>= 50%) urothelial carcinoma have been surgically resected and demonstrated to be only Ta or carcinoma in situ (CIS) (\< cT1 N0) are eligible regardless of time elapsed
- Patient must not have any uncontrolled illness including, but not limited to, ongoing or active infection including tuberculosis (clinical evaluation that includes clinical history, physical examination and radiographic findings, and tuberculosis testing in line with local practice), symptomatic congestive heart failure (CHF), myocardial infarction (MI) or unstable angina pectoris, significant uncontrolled cardiac arrhythmia, clinically relevant liver cirrhosis, interstitial lung disease, or psychiatric illness/social situations in the three months prior to registration that would limit compliance with study requirements
- Patient must not have received prior radiation therapy to \>= 25% of the bone marrow for other diseases
- Patient must not have received prior systemic anthracycline therapy
- NOTE: Patients who have received prior intravesical therapy at any time for non-muscle invasive urothelial carcinoma of the bladder are eligible
- Patient must not have either history of or active autoimmune disease requiring immunosuppressive therapy within 2 years prior to registration/randomization or any history of inflammatory bowel disease (inflammatory bowel disease \[IBD\], e.g. ulcerative colitis, or Crohn's disease), neuromuscular autoimmune condition, immune-related pneumonitis or interstitial lung disease. Patients with well-controlled hyper/hypothyroidism, celiac controlled by diet alone, diabetes mellitus type I, vitiligo, alopecia, psoriasis, eczema, lichen planus, or similar skin/mucosa condition are eligible
- Patient must not be on or have used immunosuppressive medication within 14 days prior to the first dose of durvalumab. The following are exceptions to this criterion and are allowed:
- Intranasal, inhaled, intra-auricular, topical steroids, or local steroid injections (e.g. intra-articular injection
- Systemic corticosteroids at physiologic doses not to exceed 10 mg/day of prednisone or its equivalent at the time of enrollment
- Steroids as pre-medications for hypersensitivity reactions (e.g. computed tomography \[CT\] pre-medication)
- Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months prior to registration/randomization are eligible for this trial
- NOTE: These patients must be stable on their anti-retroviral regimen with evidence of at least two undetectable viral loads within the past 6 months on the same regimen; the most recent undetectable viral load must be within the past 12 weeks. They must have a CD4 count of greater than 250 cells/mcL over the past 6 months on this same anti-retroviral regimen and must not have had a CD4 count \< 200 cells/mcL over the past 2 years, unless it was deemed related to the cancer and/or chemotherapy induced bone marrow suppression. They must not be currently receiving prophylactic therapy for an opportunistic infection and must not have had an opportunistic infection within the past 6 months
- NOTE: For patients who have received chemotherapy in the past 6 months, a CD4 count \< 250 cells/mcL during chemotherapy is permitted as long as viral loads were undetectable during this same chemotherapy. They must have an undetectable viral load and a CD4 count \>= 250 cells/mcL within 7 days of registration/randomization
- For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated
- NOTE: Testing for HIV, hepatitis B or hepatitis C is not required unless clinically indicated
- Patients with a history of hepatitis C virus (HCV) infection must have been treated and have undetectable viral load. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load
- Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better
- Patient must not have received live attenuated vaccine within 30 days prior to the first dose of durvalumab, while on protocol treatment and within 30 days after the last dose of durvalumab
- Patient must not have had a major surgical procedure within 28 days prior to registration/randomization
- NOTE: Cystoscopy/ureteroscopy/TURBT, stent placement or nephrostomy tube is not considered major surgery
- Patient must not have history of allogenic organ transplantation
- Patient must have a body weight of \> 30 kg
- Patient must have life expectancy of \>= 12 weeks
- Patient must have creatinine clearance \> 15 ml/min as estimated by Cockcroft-Gault formula or glomerular filtration rate (GFR) \> 15 ml/min/1.73m\^2 within 28 days prior to registration/randomization
- NOTE: Patients will be assigned to cisplatin-ineligible and cisplatin-eligible cohorts based on their creatinine clearance, Eastern Cooperative Oncology Group (ECOG) performance status, and grade (if any) of peripheral neuropathy and/or hearing loss in keeping with recommended cisplatin contraindications. Patients who are cisplatin-eligible will be randomized to either Arm A or Arm B and patients who are cisplatin-ineligible will be registered to Arm C
- Patients that meet any of the following four criteria will be registered to the cisplatin-ineligible Arm C if they meet other eligibility criteria:
- Creatinine clearance \> 15 ml/min and =\< 50 ml/min (estimated by Cockcroft-Gault formula) or GFR \> 15ml/min/1.73m\^2 and ≤ 50 ml/min/1.73 m\^2
- Hearing loss \>= 3
- Neuropathy \>= 2
- ECOG performance status 2
- In addition, the patient must have an absolute neutrophil count (ANC) \>= 1,000/mcL obtained =\< 14 days prior to registration
- Patients that meet all of the following four criteria will be randomized to the cisplatin-eligible Arm A or Arm B:
- Creatinine clearance \> 50ml/min (estimated by Cockcroft-Gault formula) or GFR \> 50ml/min/1.73m\^2
- ECOG performance status 0-1
- Hearing loss grade 0-2
- Neuropathy 0-1
- In addition, the patient must have an absolute neutrophil count (ANC) \>= 1,500/mcL obtained =\< 14 days prior to randomization
- Also, the patient must have left ventricular ejection fraction (LVEF) \>= 50% by (either multigated acquisition scan \[MUGA\] or 2-D echocardiogram) obtained within obtained within 28 days prior to randomization
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (258)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of New Mexico Cancer Center Coordinator of this site? Confirm its status | Albuquerque | United States | Recruiting |
| OSF Saint Anthony's Health Center Coordinator of this site? Confirm its status | Alton | United States | Suspended |
| McFarland Clinic - Ames Coordinator of this site? Confirm its status | Ames | United States | Active, not recruiting |
| Mary Greeley Medical Center Coordinator of this site? Confirm its status | Ames | United States | Active, not recruiting |
| Trinity Health Saint Joseph Mercy Hospital Ann Arbor Coordinator of this site? Confirm its status | Ann Arbor | United States | Recruiting |
| ThedaCare Regional Cancer Center Coordinator of this site? Confirm its status | Appleton | United States | Recruiting |
| Emory University Hospital Midtown Coordinator of this site? Confirm its status | Atlanta | United States | Recruiting |
| Emory Saint Joseph's Hospital Coordinator of this site? Confirm its status | Atlanta | United States | Recruiting |
| Emory University Hospital/Winship Cancer Institute Coordinator of this site? Confirm its status | Atlanta | United States | Recruiting |
| Sutter Auburn Faith Hospital Coordinator of this site? Confirm its status | Auburn | United States | Active, not recruiting |
| Harold Alfond Center for Cancer Care Coordinator of this site? Confirm its status | Augusta | United States | Recruiting |
| UCHealth University of Colorado Hospital Coordinator of this site? Confirm its status | Aurora | United States | Recruiting |
| Mercy Oncology and Hematology - Clayton-Clarkson Coordinator of this site? Confirm its status | Ballwin | United States | Suspended |
| Johns Hopkins University/Sidney Kimmel Cancer Center Coordinator of this site? Confirm its status | Baltimore | United States | Recruiting |
| Advocate Good Shepherd Hospital Coordinator of this site? Confirm its status | Barrington | United States | Recruiting |
| Mary Bird Perkins Cancer Center Coordinator of this site? Confirm its status | Baton Rouge | United States | Recruiting |
| Alta Bates Summit Medical Center-Herrick Campus Coordinator of this site? Confirm its status | Berkeley | United States | Active, not recruiting |
| University of Iowa Healthcare Cancer Services Quad Cities Coordinator of this site? Confirm its status | Bettendorf | United States | Recruiting |
| MaineHealth Maine Medical Center - Biddeford Coordinator of this site? Confirm its status | Biddeford | United States | Suspended |
| Illinois CancerCare-Bloomington Coordinator of this site? Confirm its status | Bloomington | United States | Active, not recruiting |
| Central Care Cancer Center - Bolivar Coordinator of this site? Confirm its status | Bolivar | United States | Suspended |
| McFarland Clinic - Boone Coordinator of this site? Confirm its status | Boone | United States | Active, not recruiting |
| Trinity Health IHA Medical Group Hematology Oncology - Brighton Coordinator of this site? Confirm its status | Brighton | United States | Recruiting |
| Trinity Health Medical Center - Brighton Coordinator of this site? Confirm its status | Brighton | United States | Recruiting |
| Roswell Park Cancer Institute Coordinator of this site? Confirm its status | Buffalo | United States | Active, not recruiting |
| Aurora Cancer Care-Southern Lakes VLCC Coordinator of this site? Confirm its status | Burlington | United States | Recruiting |
| Minnesota Oncology - Burnsville Coordinator of this site? Confirm its status | Burnsville | United States | Suspended |
| Fairview Ridges Hospital Coordinator of this site? Confirm its status | Burnsville | United States | Suspended |
| Loyola Center for Health at Burr Ridge Coordinator of this site? Confirm its status | Burr Ridge | United States | Active, not recruiting |
| Cambridge Medical Center Coordinator of this site? Confirm its status | Cambridge | United States | Suspended |
| Trinity Health Medical Center - Canton Coordinator of this site? Confirm its status | Canton | United States | Recruiting |
| Illinois CancerCare-Canton Coordinator of this site? Confirm its status | Canton | United States | Active, not recruiting |
| Trinity Health IHA Medical Group Hematology Oncology - Canton Coordinator of this site? Confirm its status | Canton | United States | Recruiting |
| Saint Francis Medical Center Coordinator of this site? Confirm its status | Cape Girardeau | United States | Recruiting |
| Mercy Cancer Center - Cape Girardeau Coordinator of this site? Confirm its status | Cape Girardeau | United States | Suspended |
| Memorial Hospital of Carbondale Coordinator of this site? Confirm its status | Carbondale | United States | Suspended |
| SIH Cancer Institute Coordinator of this site? Confirm its status | Carterville | United States | Recruiting |
| Illinois CancerCare-Carthage Coordinator of this site? Confirm its status | Carthage | United States | Active, not recruiting |
| Dayton Physicians LLC-Miami Valley South Coordinator of this site? Confirm its status | Centerville | United States | Active, not recruiting |
| Miami Valley Hospital South Coordinator of this site? Confirm its status | Centerville | United States | Recruiting |
| Centralia Oncology Clinic Coordinator of this site? Confirm its status | Centralia | United States | Suspended |
| Vandalia Health/CAMC Institute for Academic Medicine Coordinator of this site? Confirm its status | Charleston | United States | Recruiting |
| Medical University of South Carolina Coordinator of this site? Confirm its status | Charleston | United States | Active, not recruiting |
| Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Coordinator of this site? Confirm its status | Chelsea | United States | Recruiting |
| Chelsea Hospital Coordinator of this site? Confirm its status | Chelsea | United States | Recruiting |
| Advocate Illinois Masonic Medical Center Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
| Hematology Oncology Consultants-Clarkston Coordinator of this site? Confirm its status | Clarkston | United States | Recruiting |
| Newland Medical Associates-Clarkston Coordinator of this site? Confirm its status | Clarkston | United States | Suspended |
| Southeastern Medical Oncology Center-Clinton Coordinator of this site? Confirm its status | Clinton | United States | Recruiting |
| Mercy Hospital Coordinator of this site? Confirm its status | Coon Rapids | United States | Recruiting |
| AMG Crystal Lake - Oncology Coordinator of this site? Confirm its status | Crystal Lake | United States | Recruiting |
| UT Southwestern Simmons Cancer Center - RedBird Coordinator of this site? Confirm its status | Dallas | United States | Suspended |
| Parkland Memorial Hospital Coordinator of this site? Confirm its status | Dallas | United States | Recruiting |
| UT Southwestern/Simmons Cancer Center-Dallas Coordinator of this site? Confirm its status | Dallas | United States | Recruiting |
| Carle at The Riverfront Coordinator of this site? Confirm its status | Danville | United States | Recruiting |
| Miami Valley Hospital North Coordinator of this site? Confirm its status | Dayton | United States | Recruiting |
| Premier Blood and Cancer Center Coordinator of this site? Confirm its status | Dayton | United States | Recruiting |
| Miami Valley Hospital Coordinator of this site? Confirm its status | Dayton | United States | Recruiting |
| Dayton Physician LLC - Englewood Coordinator of this site? Confirm its status | Dayton | United States | Active, not recruiting |
| Emory Decatur Hospital Coordinator of this site? Confirm its status | Decatur | United States | Recruiting |
| Cancer Care Specialists of Illinois - Decatur Coordinator of this site? Confirm its status | Decatur | United States | Recruiting |
| Decatur Memorial Hospital Coordinator of this site? Confirm its status | Decatur | United States | Suspended |
| UCHealth - Cherry Creek Coordinator of this site? Confirm its status | Denver | United States | Recruiting |
| Illinois CancerCare-Dixon Coordinator of this site? Confirm its status | Dixon | United States | Active, not recruiting |
| Advocate Good Samaritan Hospital Coordinator of this site? Confirm its status | Downers Grove | United States | Recruiting |
| City of Hope Comprehensive Cancer Center Coordinator of this site? Confirm its status | Duarte | United States | Active, not recruiting |
| Marshfield Medical Center-EC Cancer Center Coordinator of this site? Confirm its status | Eau Claire | United States | Recruiting |
| Fairview Southdale Hospital Coordinator of this site? Confirm its status | Edina | United States | Suspended |
| Minnesota Oncology - Edina Coordinator of this site? Confirm its status | Edina | United States | Recruiting |
| Carle Physician Group-Effingham Coordinator of this site? Confirm its status | Effingham | United States | Recruiting |
| Crossroads Cancer Center Coordinator of this site? Confirm its status | Effingham | United States | Recruiting |
| Advocate Sherman Hospital Coordinator of this site? Confirm its status | Elgin | United States | Recruiting |
| UPMC Hillman Cancer Center Erie Coordinator of this site? Confirm its status | Erie | United States | Recruiting |
| Illinois CancerCare-Eureka Coordinator of this site? Confirm its status | Eureka | United States | Active, not recruiting |
| Parkland Health Center - Farmington Coordinator of this site? Confirm its status | Farmington | United States | Recruiting |
| Armes Family Cancer Center Coordinator of this site? Confirm its status | Findlay | United States | Active, not recruiting |
| Genesee Hematology Oncology PC Coordinator of this site? Confirm its status | Flint | United States | Suspended |
| Cancer Hematology Centers - Flint Coordinator of this site? Confirm its status | Flint | United States | Recruiting |
| Genesys Hurley Cancer Institute Coordinator of this site? Confirm its status | Flint | United States | Recruiting |
| Hurley Medical Center Coordinator of this site? Confirm its status | Flint | United States | Recruiting |
| Cancer Care and Hematology-Fort Collins Coordinator of this site? Confirm its status | Fort Collins | United States | Recruiting |
| Poudre Valley Hospital Coordinator of this site? Confirm its status | Fort Collins | United States | Recruiting |
| McFarland Clinic - Trinity Cancer Center Coordinator of this site? Confirm its status | Fort Dodge | United States | Active, not recruiting |
| Mercy Hospital Fort Smith Coordinator of this site? Confirm its status | Fort Smith | United States | Suspended |
| UT Southwestern/Simmons Cancer Center-Fort Worth Coordinator of this site? Confirm its status | Fort Worth | United States | Recruiting |
| Atrium Medical Center-Middletown Regional Hospital Coordinator of this site? Confirm its status | Franklin | United States | Recruiting |
| Dayton Physicians LLC-Atrium Coordinator of this site? Confirm its status | Franklin | United States | Active, not recruiting |
| Palo Alto Medical Foundation-Fremont Coordinator of this site? Confirm its status | Fremont | United States | Active, not recruiting |
| Unity Hospital Coordinator of this site? Confirm its status | Fridley | United States | Active, not recruiting |
| Illinois CancerCare-Galesburg Coordinator of this site? Confirm its status | Galesburg | United States | Active, not recruiting |
| Western Illinois Cancer Treatment Center Coordinator of this site? Confirm its status | Galesburg | United States | Suspended |
| Central Care Cancer Center - Garden City Coordinator of this site? Confirm its status | Garden City | United States | Suspended |
| Aurora Health Care Germantown Health Center Coordinator of this site? Confirm its status | Germantown | United States | Recruiting |
| Southeastern Medical Oncology Center-Goldsboro Coordinator of this site? Confirm its status | Goldsboro | United States | Recruiting |
| Aurora Cancer Care-Grafton Coordinator of this site? Confirm its status | Grafton | United States | Recruiting |
| Central Care Cancer Center - Great Bend Coordinator of this site? Confirm its status | Great Bend | United States | Suspended |
| UCHealth Greeley Hospital Coordinator of this site? Confirm its status | Greeley | United States | Recruiting |
| Aurora BayCare Medical Center Coordinator of this site? Confirm its status | Green Bay | United States | Recruiting |
| UPMC Cancer Centers - Arnold Palmer Pavilion Coordinator of this site? Confirm its status | Greensburg | United States | Recruiting |
| Miami Valley Cancer Care and Infusion Coordinator of this site? Confirm its status | Greenville | United States | Recruiting |
| Hackensack University Medical Center Coordinator of this site? Confirm its status | Hackensack | United States | Completed |
| Advocate South Suburban Hospital Coordinator of this site? Confirm its status | Hazel Crest | United States | Recruiting |
| Penn State Milton S. Hershey Medical Center Coordinator of this site? Confirm its status | Hershey | United States | Recruiting |
| UCHealth Highlands Ranch Hospital Coordinator of this site? Confirm its status | Highlands Ranch | United States | Recruiting |
| Loyola Medicine Homer Glen Coordinator of this site? Confirm its status | Homer Glen | United States | Active, not recruiting |
| University of Iowa/Holden Comprehensive Cancer Center Coordinator of this site? Confirm its status | Iowa City | United States | Recruiting |
| Southeastern Medical Oncology Center-Jacksonville Coordinator of this site? Confirm its status | Jacksonville | United States | Recruiting |
| Mayo Clinic in Florida Coordinator of this site? Confirm its status | Jacksonville | United States | Active, not recruiting |
| McFarland Clinic - Jefferson Coordinator of this site? Confirm its status | Jefferson | United States | Active, not recruiting |
| MU Health Care Goldschmidt Cancer Center Coordinator of this site? Confirm its status | Jefferson City | United States | Suspended |
| Mercy Hospital Joplin Coordinator of this site? Confirm its status | Joplin | United States | Suspended |
| Freeman Health System Coordinator of this site? Confirm its status | Joplin | United States | Suspended |
| Aurora Cancer Care-Kenosha South Coordinator of this site? Confirm its status | Kenosha | United States | Recruiting |
| Greater Dayton Cancer Center Coordinator of this site? Confirm its status | Kettering | United States | Active, not recruiting |
| Kettering Medical Center Coordinator of this site? Confirm its status | Kettering | United States | Active, not recruiting |
| Illinois CancerCare-Kewanee Clinic Coordinator of this site? Confirm its status | Kewanee | United States | Active, not recruiting |
| Kingman Regional Medical Center Coordinator of this site? Confirm its status | Kingman | United States | Recruiting |
| UC San Diego Moores Cancer Center Coordinator of this site? Confirm its status | La Jolla | United States | Recruiting |
| OptumCare Cancer Care at Charleston Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| OptumCare Cancer Care at Fort Apache Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| Cancer Centers of Southwest Oklahoma Research Coordinator of this site? Confirm its status | Lawton | United States | Recruiting |
| University of Kentucky/Markey Cancer Center Coordinator of this site? Confirm its status | Lexington | United States | Recruiting |
| AMG Libertyville - Oncology Coordinator of this site? Confirm its status | Libertyville | United States | Recruiting |
| University of Arkansas for Medical Sciences Coordinator of this site? Confirm its status | Little Rock | United States | Active, not recruiting |
| Cooperman Barnabas Medical Center Coordinator of this site? Confirm its status | Livingston | United States | Recruiting |
| Hope Cancer Clinic Coordinator of this site? Confirm its status | Livonia | United States | Suspended |
| Trinity Health Saint Mary Mercy Livonia Hospital Coordinator of this site? Confirm its status | Livonia | United States | Recruiting |
| UCHealth Lone Tree Health Center Coordinator of this site? Confirm its status | Lone Tree | United States | Recruiting |
| Medical Center of the Rockies Coordinator of this site? Confirm its status | Loveland | United States | Recruiting |
| Illinois CancerCare-Macomb Coordinator of this site? Confirm its status | Macomb | United States | Active, not recruiting |
| Henry Ford Saint John Hospital - Macomb Medical Coordinator of this site? Confirm its status | Macomb | United States | Recruiting |
| Fairview Clinics and Surgery Center Maple Grove Coordinator of this site? Confirm its status | Maple Grove | United States | Suspended |
| Minnesota Oncology Hematology PA-Maplewood Coordinator of this site? Confirm its status | Maplewood | United States | Recruiting |
| Saint John's Hospital - Healtheast Coordinator of this site? Confirm its status | Maplewood | United States | Suspended |
| Aurora Bay Area Medical Group-Marinette Coordinator of this site? Confirm its status | Marinette | United States | Recruiting |
| McFarland Clinic - Marshalltown Coordinator of this site? Confirm its status | Marshalltown | United States | Active, not recruiting |
| Marshfield Medical Center-Marshfield Coordinator of this site? Confirm its status | Marshfield | United States | Recruiting |
| Carle Physician Group-Mattoon/Charleston Coordinator of this site? Confirm its status | Mattoon | United States | Recruiting |
| Loyola University Medical Center Coordinator of this site? Confirm its status | Maywood | United States | Active, not recruiting |
| Marjorie Weinberg Cancer Center at Loyola-Gottlieb Coordinator of this site? Confirm its status | Melrose Park | United States | Active, not recruiting |
| Mary Bird Perkins Cancer Center - Metairie Coordinator of this site? Confirm its status | Metairie | United States | Recruiting |
| East Jefferson General Hospital Coordinator of this site? Confirm its status | Metairie | United States | Suspended |
| LSU Healthcare Network / Metairie Multi-Specialty Clinic Coordinator of this site? Confirm its status | Metairie | United States | Recruiting |
| Aurora Sinai Medical Center Coordinator of this site? Confirm its status | Milwaukee | United States | Recruiting |
| Aurora Saint Luke's Medical Center Coordinator of this site? Confirm its status | Milwaukee | United States | Recruiting |
| Aurora Cancer Care-Milwaukee Coordinator of this site? Confirm its status | Milwaukee | United States | Recruiting |
| Health Partners Inc Coordinator of this site? Confirm its status | Minneapolis | United States | Suspended |
| Abbott-Northwestern Hospital Coordinator of this site? Confirm its status | Minneapolis | United States | Suspended |
| Hennepin County Medical Center Coordinator of this site? Confirm its status | Minneapolis | United States | Suspended |
| Marshfield Medical Center - Minocqua Coordinator of this site? Confirm its status | Minocqua | United States | Recruiting |
| Memorial Medical Center Coordinator of this site? Confirm its status | Modesto | United States | Active, not recruiting |
| UPMC Hillman Cancer Center - Monroeville Coordinator of this site? Confirm its status | Monroeville | United States | Recruiting |
| Monticello Cancer Center Coordinator of this site? Confirm its status | Monticello | United States | Suspended |
| Palo Alto Medical Foundation-Camino Division Coordinator of this site? Confirm its status | Mountain View | United States | Active, not recruiting |
| SSM Health Good Samaritan Coordinator of this site? Confirm its status | Mount Vernon | United States | Recruiting |
| ProHealth D N Greenwald Center Coordinator of this site? Confirm its status | Mukwonago | United States | Recruiting |
| Saint Alphonsus Cancer Care Center-Nampa Coordinator of this site? Confirm its status | Nampa | United States | Recruiting |
| Rutgers Cancer Institute of New Jersey Coordinator of this site? Confirm its status | New Brunswick | United States | Recruiting |
| University Medical Center New Orleans Coordinator of this site? Confirm its status | New Orleans | United States | Recruiting |
| Cancer Center of Western Wisconsin Coordinator of this site? Confirm its status | New Richmond | United States | Suspended |
| New Ulm Medical Center Coordinator of this site? Confirm its status | New Ulm | United States | Suspended |
| Advocate Christ Medical Center Coordinator of this site? Confirm its status | Oak Lawn | United States | Recruiting |
| ProHealth Oconomowoc Memorial Hospital Coordinator of this site? Confirm its status | Oconomowoc | United States | Recruiting |
| Cancer Care Center of O'Fallon Coordinator of this site? Confirm its status | O'Fallon | United States | Recruiting |
| Mercy Hospital Oklahoma City Coordinator of this site? Confirm its status | Oklahoma City | United States | Suspended |
| University of Oklahoma Health Sciences Center Coordinator of this site? Confirm its status | Oklahoma City | United States | Recruiting |
| Vince Lombardi Cancer Clinic - Oshkosh Coordinator of this site? Confirm its status | Oshkosh | United States | Recruiting |
| Illinois CancerCare-Ottawa Clinic Coordinator of this site? Confirm its status | Ottawa | United States | Active, not recruiting |
| Stanford Cancer Institute Palo Alto Coordinator of this site? Confirm its status | Palo Alto | United States | Recruiting |
| Palo Alto Medical Foundation Health Care Coordinator of this site? Confirm its status | Palo Alto | United States | Active, not recruiting |
| Advocate Lutheran General Hospital Coordinator of this site? Confirm its status | Park Ridge | United States | Recruiting |
| Illinois CancerCare-Pekin Coordinator of this site? Confirm its status | Pekin | United States | Active, not recruiting |
| Methodist Medical Center of Illinois Coordinator of this site? Confirm its status | Peoria | United States | Suspended |
| Illinois CancerCare-Peoria Coordinator of this site? Confirm its status | Peoria | United States | Active, not recruiting |
| Illinois CancerCare-Peru Coordinator of this site? Confirm its status | Peru | United States | Active, not recruiting |
| Valley Radiation Oncology Coordinator of this site? Confirm its status | Peru | United States | Suspended |
| Thomas Jefferson University Hospital Coordinator of this site? Confirm its status | Philadelphia | United States | Recruiting |
| University of Pennsylvania/Abramson Cancer Center Coordinator of this site? Confirm its status | Philadelphia | United States | Recruiting |
| UPMC-Passavant Hospital Coordinator of this site? Confirm its status | Pittsburgh | United States | Recruiting |
| UPMC-Saint Clair Hospital Cancer Center Coordinator of this site? Confirm its status | Pittsburgh | United States | Recruiting |
| UPMC Hillman Cancer Center Coordinator of this site? Confirm its status | Pittsburgh | United States | Recruiting |
| Trinity Health Saint Joseph Mercy Oakland Hospital Coordinator of this site? Confirm its status | Pontiac | United States | Recruiting |
| Michigan Healthcare Professionals Pontiac Coordinator of this site? Confirm its status | Pontiac | United States | Recruiting |
| Trinity Health IHA Medical Group-Alice Gustafson Center Coordinator of this site? Confirm its status | Pontiac | United States | Recruiting |
| Fairview Northland Medical Center Coordinator of this site? Confirm its status | Princeton | United States | Suspended |
| Illinois CancerCare-Princeton Coordinator of this site? Confirm its status | Princeton | United States | Active, not recruiting |
| Aurora Cancer Care-Racine Coordinator of this site? Confirm its status | Racine | United States | Recruiting |
| Marshfield Medical Center-Rice Lake Coordinator of this site? Confirm its status | Rice Lake | United States | Recruiting |
| UT Southwestern Clinical Center at Richardson/Plano Coordinator of this site? Confirm its status | Richardson | United States | Recruiting |
| Reid Health Coordinator of this site? Confirm its status | Richmond | United States | Active, not recruiting |
| North Memorial Medical Health Center Coordinator of this site? Confirm its status | Robbinsdale | United States | Suspended |
| Mayo Clinic in Rochester Coordinator of this site? Confirm its status | Rochester | United States | Recruiting |
| Phelps Health Delbert Day Cancer Institute Coordinator of this site? Confirm its status | Rolla | United States | Suspended |
| Mercy Clinic-Rolla-Cancer and Hematology Coordinator of this site? Confirm its status | Rolla | United States | Suspended |
| Sutter Roseville Medical Center Coordinator of this site? Confirm its status | Roseville | United States | Active, not recruiting |
| Sutter Medical Center Sacramento Coordinator of this site? Confirm its status | Sacramento | United States | Active, not recruiting |
| MyMichigan Medical Center Saginaw Coordinator of this site? Confirm its status | Saginaw | United States | Recruiting |
| Oncology Hematology Associates of Saginaw Valley PC Coordinator of this site? Confirm its status | Saginaw | United States | Suspended |
| Sainte Genevieve County Memorial Hospital Coordinator of this site? Confirm its status | Sainte Genevieve | United States | Recruiting |
| Heartland Regional Medical Center Coordinator of this site? Confirm its status | Saint Joseph | United States | Suspended |
| Park Nicollet Clinic - Saint Louis Park Coordinator of this site? Confirm its status | Saint Louis Park | United States | Recruiting |
| Regions Hospital Coordinator of this site? Confirm its status | Saint Paul | United States | Recruiting |
| United Hospital Coordinator of this site? Confirm its status | Saint Paul | United States | Suspended |
| UC San Diego Medical Center - Hillcrest Coordinator of this site? Confirm its status | San Diego | United States | Recruiting |
| MaineHealth Cancer Care Center of York County Coordinator of this site? Confirm its status | Sanford | United States | Recruiting |
| MaineHealth Cancer Care and IV Therapy - Sanford Coordinator of this site? Confirm its status | Sanford | United States | Recruiting |
| California Pacific Medical Center-Pacific Campus Coordinator of this site? Confirm its status | San Francisco | United States | Active, not recruiting |
| Palo Alto Medical Foundation-Santa Cruz Coordinator of this site? Confirm its status | Santa Cruz | United States | Active, not recruiting |
| Sutter Pacific Medical Foundation Coordinator of this site? Confirm its status | Santa Rosa | United States | Active, not recruiting |
| MaineHealth Maine Medical Center- Scarborough Coordinator of this site? Confirm its status | Scarborough | United States | Recruiting |
| University of Washington Medical Center - Montlake Coordinator of this site? Confirm its status | Seattle | United States | Recruiting |
| Fred Hutchinson Cancer Center Coordinator of this site? Confirm its status | Seattle | United States | Recruiting |
| Saint Francis Regional Medical Center Coordinator of this site? Confirm its status | Shakopee | United States | Suspended |
| Vince Lombardi Cancer Clinic-Sheboygan Coordinator of this site? Confirm its status | Sheboygan | United States | Recruiting |
| MaineHealth Cancer Care and IV Therapy - South Portland Coordinator of this site? Confirm its status | South Portland | United States | Recruiting |
| Southern Illinois University School of Medicine Coordinator of this site? Confirm its status | Springfield | United States | Recruiting |
| Springfield Memorial Hospital Coordinator of this site? Confirm its status | Springfield | United States | Suspended |
| Springfield Regional Cancer Center Coordinator of this site? Confirm its status | Springfield | United States | Suspended |
| CoxHealth South Hospital Coordinator of this site? Confirm its status | Springfield | United States | Suspended |
| Mercy Hospital Springfield Coordinator of this site? Confirm its status | Springfield | United States | Suspended |
| Springfield Clinic Coordinator of this site? Confirm its status | Springfield | United States | Recruiting |
| Marshfield Medical Center-River Region at Stevens Point Coordinator of this site? Confirm its status | Stevens Point | United States | Recruiting |
| Lakeview Hospital Coordinator of this site? Confirm its status | Stillwater | United States | Recruiting |
| Mercy Hospital Saint Louis Coordinator of this site? Confirm its status | St Louis | United States | Recruiting |
| Mercy Hospital South Coordinator of this site? Confirm its status | St Louis | United States | Recruiting |
| Mercy Infusion Center - Chippewa Coordinator of this site? Confirm its status | St Louis | United States | Suspended |
| Missouri Baptist Medical Center Coordinator of this site? Confirm its status | St Louis | United States | Recruiting |
| Missouri Baptist Sullivan Hospital Coordinator of this site? Confirm its status | Sullivan | United States | Recruiting |
| Aurora Medical Center in Summit Coordinator of this site? Confirm its status | Summit | United States | Recruiting |
| Palo Alto Medical Foundation-Sunnyvale Coordinator of this site? Confirm its status | Sunnyvale | United States | Active, not recruiting |
| ProMedica Flower Hospital Coordinator of this site? Confirm its status | Sylvania | United States | Recruiting |
| MyMichigan Medical Center Tawas Coordinator of this site? Confirm its status | Tawas City | United States | Recruiting |
| Community Medical Center Coordinator of this site? Confirm its status | Toms River | United States | Recruiting |
| Upper Valley Medical Center Coordinator of this site? Confirm its status | Troy | United States | Recruiting |
| Vince Lombardi Cancer Clinic-Two Rivers Coordinator of this site? Confirm its status | Two Rivers | United States | Recruiting |
| Carle Cancer Center Coordinator of this site? Confirm its status | Urbana | United States | Recruiting |
| Sutter Solano Medical Center/Cancer Center Coordinator of this site? Confirm its status | Vallejo | United States | Active, not recruiting |
| Ridgeview Medical Center Coordinator of this site? Confirm its status | Waconia | United States | Suspended |
| Illinois CancerCare - Washington Coordinator of this site? Confirm its status | Washington | United States | Active, not recruiting |
| Mercy Hospital Washington Coordinator of this site? Confirm its status | Washington | United States | Suspended |
| UPMC Cancer Center-Washington Coordinator of this site? Confirm its status | Washington | United States | Recruiting |
| MedStar Washington Hospital Center Coordinator of this site? Confirm its status | Washington D.C. | United States | Recruiting |
| Sibley Memorial Hospital Coordinator of this site? Confirm its status | Washington D.C. | United States | Recruiting |
| ProHealth Waukesha Memorial Hospital Coordinator of this site? Confirm its status | Waukesha | United States | Recruiting |
| UW Cancer Center at ProHealth Care Coordinator of this site? Confirm its status | Waukesha | United States | Recruiting |
| ThedaCare Cancer Care - Waupaca Coordinator of this site? Confirm its status | Waupaca | United States | Recruiting |
| Aurora Cancer Care-Milwaukee West Coordinator of this site? Confirm its status | Wauwatosa | United States | Recruiting |
| Aurora West Allis Medical Center Coordinator of this site? Confirm its status | West Allis | United States | Recruiting |
| Saint Mary's Oncology/Hematology Associates of West Branch Coordinator of this site? Confirm its status | West Branch | United States | Suspended |
| Marshfield Medical Center - Weston Coordinator of this site? Confirm its status | Weston | United States | Recruiting |
| Reading Hospital Coordinator of this site? Confirm its status | West Reading | United States | Recruiting |
| Rice Memorial Hospital Coordinator of this site? Confirm its status | Willmar | United States | Suspended |
| Wake Forest University Health Sciences Coordinator of this site? Confirm its status | Winston-Salem | United States | Active, not recruiting |
| Minnesota Oncology Hematology PA-Woodbury Coordinator of this site? Confirm its status | Woodbury | United States | Recruiting |
| UMass Memorial Medical Center - University Campus Coordinator of this site? Confirm its status | Worcester | United States | Recruiting |
| Fairview Lakes Medical Center Coordinator of this site? Confirm its status | Wyoming | United States | Suspended |
| Huron Gastroenterology PC Coordinator of this site? Confirm its status | Ypsilanti | United States | Recruiting |
| Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Coordinator of this site? Confirm its status | Ypsilanti | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.