NCT04630808CompletedPhase 3
MRCT Evaluating NCX 470 vs. Latanoprost in Subjects With Open-Angle Glaucoma or Ocular Hypertension
A Phase 3, Randomized, Multi-Regional, Double-Masked, Parallel-Group Trial Evaluating the Safety and Efficacy of NCX 470 0.1% vs. Latanoprost 0.005% in Subjects With Open-Angle Glaucoma or Ocular Hypertension (Denali)
Source: ClinicalTrials.gov · Last updated 8 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The objective of this clinical study is to evaluate the safety and efficacy of NCX 470 Ophthalmic Solution in lowering intraocular pressure (IOP) in subjecs with ocular hypertension or open-angle glaucoma. Subjects will be randomized in a 1:1 ratio to NCX 470 0.1% or to latanoprost 0.005% to be administered to both eyes once daily in the evening for up to 12 months.
- Status (registry)
- Completed
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 696 (actual)
- First submitted
- 11 Nov 2020
- Start date
- 9 Nov 2020
- Primary completion date
- 11 Apr 2025
- Lead sponsor
- Nicox Ophthalmics, Inc.
- Diseases
- Glaucoma, High blood pressure
- NCT number
- NCT04630808
What you commit to
- Study type: Interventional · Phase 3
- Participants enrolled: 696
- From 9 Nov 2020 to the primary completion date, 11 Apr 2025
- 76 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous complicated surgery or certain types of glaucoma surgery in either eye
- Incisional ocular surgery or severe trauma in either eye within the past 6 months
Other illness
- Clinically significant ocular disease in either eye
- Uncontrolled systemic disease
Other
- Narrow anterior chamber angles or disqualifying corneal thickness in either eye
Who the study is looking for
- Diagnosis of open-angle glaucoma or ocular hypertension in both eyes
- Qualifying IOP at 3 time points through the day at 2 visits following washout of IOP-lowering medication, if applicable
- Qualifying best-corrected visual acuity in each eye
- Ability to provide informed consent and follow study instructions
Age in the registry: 18 years to 84 years · Sex: All · Does not accept healthy volunteers
Sites (76)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Nicox Clinical Site Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Changchun | China | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Changsha | China | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Chengdu | China | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Chongqing | China | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Dalian | China | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Harbin | China | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Jinan | China | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Lanzhou | China | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Nanchang | China | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Qingdao | China | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Shantou | China | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Tianjing | China | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Wenzhou | China | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Wuhan | China | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Xi'an | China | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Yichang | China | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Zhengzhou | China | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Asheville | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Austin | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Bangor | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Bellevue | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Boynton Beach | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Burbank | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Chandler | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Chaska | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Clifton Park | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Cranberry Township | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Danbury | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Delray Beach | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Dothan | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | El Paso | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Eugene | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Falls Church | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Fargo | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Fort Lauderdale | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Fort Myers | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Garden Grove | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Grand Rapids | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Huntington Beach | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Indianapolis | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Jacksonville | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Jupiter | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Kansas City | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Kingston | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | La Jolla | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Lakeland | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Lancaster | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Largo | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Memphis | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Mission | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Morrow | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Mt. Dora | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Murrieta | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Newport Beach | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Pasadena | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Peoria | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Petaluma | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Phoenix | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Redlands | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Rock Island | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Roswell | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | San Francisco | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Seattle | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | St. George | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Sugar Land | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | The Bronx | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Troy | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Venice | United States | Unknown status |
| Nicox Clinical Site Coordinator of this site? Confirm its status | Winston-Salem | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.