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NCT04630808CompletedPhase 3

MRCT Evaluating NCX 470 vs. Latanoprost in Subjects With Open-Angle Glaucoma or Ocular Hypertension

A Phase 3, Randomized, Multi-Regional, Double-Masked, Parallel-Group Trial Evaluating the Safety and Efficacy of NCX 470 0.1% vs. Latanoprost 0.005% in Subjects With Open-Angle Glaucoma or Ocular Hypertension (Denali)

Source: ClinicalTrials.gov · Last updated 8 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open

Brief summary (registry, in English)

The objective of this clinical study is to evaluate the safety and efficacy of NCX 470 Ophthalmic Solution in lowering intraocular pressure (IOP) in subjecs with ocular hypertension or open-angle glaucoma. Subjects will be randomized in a 1:1 ratio to NCX 470 0.1% or to latanoprost 0.005% to be administered to both eyes once daily in the evening for up to 12 months.

Status (registry)
Completed
Phase (registry)
Phase 3
Study type
Interventional
Enrollment
696 (actual)
First submitted
11 Nov 2020
Start date
9 Nov 2020
Primary completion date
11 Apr 2025
Lead sponsor
Nicox Ophthalmics, Inc.
NCT number
NCT04630808

What you commit to

  • Study type: Interventional · Phase 3
  • Participants enrolled: 696
  • From 9 Nov 2020 to the primary completion date, 11 Apr 2025
  • 76 sites in 2 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Previous complicated surgery or certain types of glaucoma surgery in either eye
  • Incisional ocular surgery or severe trauma in either eye within the past 6 months

Other illness

  • Clinically significant ocular disease in either eye
  • Uncontrolled systemic disease

Other

  • Narrow anterior chamber angles or disqualifying corneal thickness in either eye

Who the study is looking for

  • Diagnosis of open-angle glaucoma or ocular hypertension in both eyes
  • Qualifying IOP at 3 time points through the day at 2 visits following washout of IOP-lowering medication, if applicable
  • Qualifying best-corrected visual acuity in each eye
  • Ability to provide informed consent and follow study instructions

Age in the registry: 18 years to 84 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (76)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Nicox Clinical Site
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BeijingChinaUnknown status
Nicox Clinical Site
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ChangchunChinaUnknown status
Nicox Clinical Site
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ChangshaChinaUnknown status
Nicox Clinical Site
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ChengduChinaUnknown status
Nicox Clinical Site
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ChongqingChinaUnknown status
Nicox Clinical Site
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DalianChinaUnknown status
Nicox Clinical Site
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HarbinChinaUnknown status
Nicox Clinical Site
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JinanChinaUnknown status
Nicox Clinical Site
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LanzhouChinaUnknown status
Nicox Clinical Site
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NanchangChinaUnknown status
Nicox Clinical Site
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QingdaoChinaUnknown status
Nicox Clinical Site
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ShanghaiChinaUnknown status
Nicox Clinical Site
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ShantouChinaUnknown status
Nicox Clinical Site
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TianjingChinaUnknown status
Nicox Clinical Site
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WenzhouChinaUnknown status
Nicox Clinical Site
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WuhanChinaUnknown status
Nicox Clinical Site
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Xi'anChinaUnknown status
Nicox Clinical Site
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YichangChinaUnknown status
Nicox Clinical Site
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ZhengzhouChinaUnknown status
Nicox Clinical Site
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AshevilleUnited StatesUnknown status
Nicox Clinical Site
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AustinUnited StatesUnknown status
Nicox Clinical Site
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BangorUnited StatesUnknown status
Nicox Clinical Site
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BellevueUnited StatesUnknown status
Nicox Clinical Site
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BostonUnited StatesUnknown status
Nicox Clinical Site
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Boynton BeachUnited StatesUnknown status
Nicox Clinical Site
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BurbankUnited StatesUnknown status
Nicox Clinical Site
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ChandlerUnited StatesUnknown status
Nicox Clinical Site
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ChaskaUnited StatesUnknown status
Nicox Clinical Site
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CincinnatiUnited StatesUnknown status
Nicox Clinical Site
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Clifton ParkUnited StatesUnknown status
Nicox Clinical Site
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Cranberry TownshipUnited StatesUnknown status
Nicox Clinical Site
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DanburyUnited StatesUnknown status
Nicox Clinical Site
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Delray BeachUnited StatesUnknown status
Nicox Clinical Site
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DothanUnited StatesUnknown status
Nicox Clinical Site
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El PasoUnited StatesUnknown status
Nicox Clinical Site
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EugeneUnited StatesUnknown status
Nicox Clinical Site
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Falls ChurchUnited StatesUnknown status
Nicox Clinical Site
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FargoUnited StatesUnknown status
Nicox Clinical Site
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Fort LauderdaleUnited StatesUnknown status
Nicox Clinical Site
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Fort MyersUnited StatesUnknown status
Nicox Clinical Site
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Garden GroveUnited StatesUnknown status
Nicox Clinical Site
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Grand RapidsUnited StatesUnknown status
Nicox Clinical Site
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HoustonUnited StatesUnknown status
Nicox Clinical Site
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Huntington BeachUnited StatesUnknown status
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IndianapolisUnited StatesUnknown status
Nicox Clinical Site
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JacksonvilleUnited StatesUnknown status
Nicox Clinical Site
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JupiterUnited StatesUnknown status
Nicox Clinical Site
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Kansas CityUnited StatesUnknown status
Nicox Clinical Site
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KingstonUnited StatesUnknown status
Nicox Clinical Site
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La JollaUnited StatesUnknown status
Nicox Clinical Site
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LakelandUnited StatesUnknown status
Nicox Clinical Site
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LancasterUnited StatesUnknown status
Nicox Clinical Site
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LargoUnited StatesUnknown status
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MemphisUnited StatesUnknown status
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MissionUnited StatesUnknown status
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MorrowUnited StatesUnknown status
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Mt. DoraUnited StatesUnknown status
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MurrietaUnited StatesUnknown status
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Newport BeachUnited StatesUnknown status
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PasadenaUnited StatesUnknown status
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PeoriaUnited StatesUnknown status
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PetalumaUnited StatesUnknown status
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PhoenixUnited StatesUnknown status
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RedlandsUnited StatesUnknown status
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Rock IslandUnited StatesUnknown status
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RoswellUnited StatesUnknown status
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San AntonioUnited StatesUnknown status
Nicox Clinical Site
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San FranciscoUnited StatesUnknown status
Nicox Clinical Site
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SeattleUnited StatesUnknown status
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St. GeorgeUnited StatesUnknown status
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St LouisUnited StatesUnknown status
Nicox Clinical Site
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Sugar LandUnited StatesUnknown status
Nicox Clinical Site
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The BronxUnited StatesUnknown status
Nicox Clinical Site
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TroyUnited StatesUnknown status
Nicox Clinical Site
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VeniceUnited StatesUnknown status
Nicox Clinical Site
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Winston-SalemUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.