NCT04634643Recruiting
Pathogenesis of Pediatric Nonalcoholic Fatty Liver Disease (NAFLD)
Pathophysiologic Mechanisms Leading to Intrahepatic Fat Accumulation in Obese Youth
Source: ClinicalTrials.gov · Last updated 30 Jul 2026
Brief summary (registry, in English)
The main aim of the study is to discover the mechanisms underlying the pathophysiology of NAFLD in obese youth.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 260 (estimated)
- First submitted
- 17 Nov 2020
- Start date
- 28 Jun 2021
- Primary completion date
- 30 Jan 2027
- Lead sponsor
- Yale University
- Diseases
- Obesity, Fatty liver disease (MASLD/MASH)
- NCT number
- NCT04634643
What you commit to
- Study type: Observational
- Planned participants: 260
- From 28 Jun 2021 to the primary completion date, 30 Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- use of drugs affecting intrahepatic fat content (e.g.; liraglutide, fish oil, etc.).
Other illness
- the presence of endocrinopathies (e.g. Cushing syndrome);
- cardiac or pulmonary or other significant chronic illness;
- adolescents with a psychiatric disorder or with substance abuse;
- monogenic obesity syndromes;
Lab values
- Baseline creatinine \>1.0 mg; pregnancy;
Who the study is looking for
- Good general health, taking no medication on a chronic basis;
- age 12 to 18 years, in puberty (girls and boys: Tanner stage II-V);
- BMI \>85th for obese cohort;
Age in the registry: 12 years to 18 years · Sex: All
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Yale New Haven Hospital Coordinator of this site? Confirm its status | New Haven | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.