NCT04645381Active, not recruiting
Bone Erosions in Rheumatoid Arthritis - Characterization Evaluated by Imaging and Histology
Source: ClinicalTrials.gov · Last updated 4 May 2026
Brief summary (registry, in English)
The aim of this study is to describe macro- and micro anatomical structures, including investigating vessels running in osseous pores in finger joints from participants with rheumatoid arthritis (RA) using histology and different imaging modalities. The perspectives are to increase understanding of the macro- and micro anatomic basis for bone erosions in RA, and possibly to provide new insights to the monitoring of patients with RA.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 9 (actual)
- First submitted
- 20 Nov 2020
- Start date
- 1 Nov 2020
- Primary completion date
- 1 May 2026
- Lead sponsor
- University of Aarhus
- Diseases
- Rheumatoid arthritis
- NCT number
- NCT04645381
What you commit to
- Study type: Observational
- Participants enrolled: 9
- From 1 Nov 2020 to the primary completion date, 1 May 2026
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Active malignant disease, hypercalcemia, poor kidney function (estimated glomerular filtration rate \< 35 mL/min), untreated hypo-/hyperthyroidism, pregnancy or wish thereof, previously fracture/dislocation of the investigated joint or metal prosthesis in joints of the investigated hand.
- Bone sample will be excluded from analysis, if the following is present:
- \- Bone not adequate for analysis (fractured bone samples).
Other
- Unable to give written informed consent.
Who the study is looking for
- Age \> 18 years
- Participants diagnosed with RA according to the ACR/EULAR (2010) classification criteria or American Rheumatism Association 1987 revised criteria for the patients who were diagnosed before 2010.
- Indication for prosthesis surgery with total joint replacement of the MCP joint according to the clinical procedure (often radiological signs of OA in the MCP joint, joint pain, angular deformity and/or impairment of daily functions).
Criteria the registry did not label
- RA Participants:
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Aarhus University Hospital Coordinator of this site? Confirm its status | Aarhus | Denmark | Unknown status |
| Regional Hospital Holstebro Coordinator of this site? Confirm its status | Holstebro | Denmark | Unknown status |
Related publications
- Mapping the bare area and transcortical pores in finger joints: co-location with bone erosions in rheumatoid arthritis.RMD Open · 2026 · PMID 41571324
This page is information, not medical advice. Discuss any trial with your doctor.