NCT04645693Completed
The Impact of Oral Health in HIV Patients on Antiretroviral Therapy
The Impact of Oral Health on Metabolism and Persistent Inflammation in HIV Patients on Antiretroviral Therapy
Source: ClinicalTrials.gov · Last updated 5 May 2026
Brief summary (registry, in English)
This is a prospective cohort study designed to investigate the range of metabolic abnormalities observed in patients living with HIV on antiretroviral therapy. This study will also explore the concurrent role of poor oral health in supporting and driving chronic immune activation and inflammation in HIV infection.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 227 (actual)
- First submitted
- 1 Oct 2020
- Start date
- 24 Feb 2021
- Primary completion date
- 28 Feb 2026
- Lead sponsor
- University of Pennsylvania
- Diseases
- HIV
- NCT number
- NCT04645693
What you commit to
- Study type: Observational
- Participants enrolled: 227
- From 24 Feb 2021 to the primary completion date, 28 Feb 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Has never received radiation therapy to the head or neck (including radioactive iodine therapy)
- Was taking anti-osteoporotic agents (biphosphonates, denosumab) prior to HIV diagnosis.
Other illness
- Has been diagnosed with the following xerostomia-related autoimmune conditions: Sjorgen's and sarcoidosis
Other
- Women who are pregnant at the time of enrollment.
Who the study is looking for
- Age ≥18 years
- Has been diagnosed with HIV (as documented by a prior laboratory report of positive HIV-1/2 antibody and/or detectable HIV RNA, available for review by the study team)
- Has received antiretroviral therapy for at least 12 months
- Able and willing to provide informed consent prior to initiation of study procedures
- Willing and able to comply with all study procedures, and likely to be available for the duration of the study
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Pennsylvania School of Dental Medicine Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.