NCT04650932Recruiting
Dual Frequency Stimulation in Parkinson's Disease
Dual Frequency, Dual Region Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease
Source: ClinicalTrials.gov · Last updated 14 Sept 2026
Brief summary (registry, in English)
Deep brain stimulation (DBS) in the dorsal region of the subthalamic nucleus (STN) is very effective for reducing motor symptoms of Parkinson's disease (PD). Modeling studies suggest that this therapy may result in current spread into the ventral STN, causing altered cognitive processes. As a result, current stimulation parameters often lead to worsening in verbal fluency, executive function, and, particularly, cognitive control. There is evidence suggesting that low frequency oscillatory activity occurs across brain circuits important in integrating information for cognition. Preclinical studies and human recording studies indicate these low frequency theta oscillations drive cognitive control during cognitive tasks. Thus, the purpose of this study is to determine the safety, tolerability, and efficacy of low frequency stimulation (LFS) of the ventral STN alongside standard high frequency stimulation (HFS) of the dorsal STN in patients with PD.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 10 (estimated)
- First submitted
- 16 Nov 2020
- Start date
- 22 Oct 2022
- Primary completion date
- 30 Dec 2026
- Lead sponsor
- University of California, Davis
- Diseases
- Parkinson disease
- NCT number
- NCT04650932
What you commit to
- Study type: Interventional
- Planned participants: 10
- From 22 Oct 2022 to the primary completion date, 30 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Pregnant women (note: pregnant women are not candidates for DBS surgery), and prisoners
Other
- Individuals unable to provide consent and/or lack capacity to consent
- Individuals diagnosed with any cognitive or physical impairments that would limit their ability to participate in the cognitive testing
- Individuals who score below 15 on the Montreal Cognitive Assessment Test-Blind
- Individuals who score above 20 on the Center for Epidemiologic Studies Depression Scale
- Non-English speaking individuals. Cognitive tasks will only be conducted in English.
Who the study is looking for
- Individuals who are 18 years and older
- Individuals with idiopathic Parkinson's Disease who previously underwent implantation with the Boston Scientific VerciseTM DBS system
- Individuals who have been implanted with the Boston Scientific VerciseTM DBS system for at least 3 months
- Individuals diagnosed with advanced PD who had bilateral dorsal subthalamic nucleus DBS surgery, as standard of care for motor improvement, with distal contacts of the electrodes implanted into the ventral STN
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UC Davis Health Coordinator of this site? Confirm its status | Sacramento | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.