NCT04656210Active, not recruiting
Myotonic Dystrophy - Vascular and Cognition
Links Between Diabetes and Cognitive Impairment in Myotonic Dystrophy Type 1 : a Non-conventional MRI Study
Source: ClinicalTrials.gov · Last updated 22 May 2026
Brief summary (registry, in English)
The cognitive disorders of adult forms of myotonic dystrophies type 1 are heterogeneous (impairment of executive functions, visio construction and theory of the mind, which can progress to the stage of dementia). Nevertheless, patients have very different degrees of cognitive impairment. Expansion of CTG triplets disrupts the alternative splicing of mRNAs of various proteins, including the insulin receptor and Tau protein. Type 2 diabetes, associated with peripheral insulin resistance, is therefore common in this pathology. Type 2 diabetes,could to explain the cognitive impairment of patients, through the accelerated development of brain lesions (especially tauopathy and cerebral atrophy).
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 85 (actual)
- First submitted
- 23 Nov 2020
- Start date
- 14 Oct 2021
- Primary completion date
- 13 Oct 2024
- Lead sponsor
- University Hospital, Lille
- Diseases
- Type 1 diabetes
- NCT number
- NCT04656210
What you commit to
- Study type: Observational
- Participants enrolled: 85
- From 14 Oct 2021 to the primary completion date, 13 Oct 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Neurological history other than neuropathy: epilepsy, stroke, dementia
- Major comorbidity considered as a contraindication by the investigator (cancer, unstable angina, etc.).
Age
- Pregnancy or breastfeeding or woman of childbearing age without effective contraception (a pregnancy test will be done)
- Persons of full age deprived of their liberties by a judicial or administrative decision
Other
- Contra indication to MRI
- Person under guardianship or curators
Who the study is looking for
- Molecularly proven type 1 myotonic dystrophy
- Voluntary, having given informed consent
- Socially insured patient
- Patient willing to comply with all study procedures and duration (3 hours + MRI 35 minutes)
- Patient insured under the French social security system
- Signed consent form
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hopital Roger Salengro, CHU Lille Coordinator of this site? Confirm its status | Lille | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.