NCT04657042Recruiting
4D-MRI for Precision Medicine
Toward Precision Radiotherapy: Physiological Modeling of Respiratory Motion Based on Ultra-quality 4D-MRI
Source: ClinicalTrials.gov · Last updated 6 May 2026
Brief summary (registry, in English)
The purpose of this study is to develop new ways to make medical images of the lungs and liver of adults using a technique called four-dimensional magnetic resonance imaging (4D-MRI). This technique produces three-dimensional movies of the inside of the chest and abdomen while the patient is breathing. (The fourth dimension is time!) This new way of medical imaging is being developed to help cancer patients undergoing radiation therapy. Radiation therapy is used to treat cancerous tumors. For radiation therapy to be effective, the precise size, shape, and location of the tumor within the body must be known. A particular difficulty for radiation treatment of lung and liver cancer is that the tumor moves during treatment because the patient is breathing. Therefore, tumor motion must also be incorporated into the treatment plan. This study aims to improve radiation treatment planning through better targeting and dose estimation based on 4D-MRI. Before this new imaging method can be used for radiation treatment planning, it must be tested in living, breathing volunteers.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 100 (estimated)
- First submitted
- 23 Nov 2020
- Start date
- 5 Nov 2020
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- University of Virginia
- NCT number
- NCT04657042
What you commit to
- Study type: Observational
- Planned participants: 100
- From 5 Nov 2020 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Any condition for which a MRI procedure is contraindicated including presence of metallic material in the body, such as pacemakers, non- MRI compatible surgical clips, shrapnel, etc.
- Patients with any serious/poorly controlled medical or psychological conditions that would complicate protocol compliance
- Presence of active or chronic infection
Other
- Subjects who have difficulty lying flat on their back for extended periods of time
- Too large to adequately fit in the magnet bore or RF coils
- Claustrophobia
- Females who are pregnant or lactating
Who the study is looking for
- Patient is 21 or older
- Patient has primary or metastatic tumor(s) in the lungs or the liver
- Diameter of the tumor(s) is less than 7 cm
- Patient will receive radiation therapy (ordered by the treating Radiation Oncologist) as part of their treatment regimen
- Patient will undergo a planning CT scan with tumor motion assessment (planning 4D-CT ordered by the treating Radiation Oncologist) as part of their treatment regimen
- Patient has signed informed consent and is willing to comply with the 4D-MRI imaging protocol
- The inclusion criteria for healthy volunteers are:
- Subject is 18 or older
- Subject has signed informed consent and is willing to comply with the 4D-MRI imaging protocol
Age in the registry: 18 years to 82 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Virginia Coordinator of this site? Confirm its status | Charlottesville | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.