NCT04657835Not yet recruiting
Multiparametric MRI Assessment of Atrial Heart Disease as a Predictor of Atrial Fibrillation After Myocardial Revascularization Surgery
Source: ClinicalTrials.gov · Last updated 7 Oct 2026
Brief summary (registry, in English)
Postoperative atrial fibrillation (POAF) occurs in 20-40% of patients undergoing coronary artery bypass grafting (CABG) and is a marker of atrial vulnerability. It is strongly associated with AF recurrence, stroke, and cardiovascular mortality. It presents risk factors with atrial heart disease. The latter refers to all structural, electrical, and mechanical alterations of the atrium that create a substrate conducive to AF. Multiparametric cardiac MRI is currently the most comprehensive test for assessing atrial heart disease, thanks to its structural and functional analysis (atrial fibrosis, atrial strain, intracavitary 4D flow). However, to date, no prospective study has evaluated these parameters as predictors of AF recurrence after CAP. At the same time, an implantable Holter monitor will be used to enable detailed and continuous detection of recurrence episodes, overcoming the limitations of conventional monitoring strategies. By combining multiparametric imaging, histological analysis, and continuous monitoring for the first time, this study proposes a paradigm shift in the assessment of postoperative AF: moving from a descriptive and ad hoc approach to a mechanistic, integrative, and predictive approach.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- First submitted
- 24 Nov 2020
- Start date
- 1 Oct 2026
- Primary completion date
- Dec 2028
- Lead sponsor
- Centre Hospitalier Universitaire de Saint Etienne
- Diseases
- Atrial fibrillation
- NCT number
- NCT04657835
What you commit to
- Study type: Interventional
- Planned participants: 100
- From 1 Oct 2026 to the primary completion date, Dec 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Concomitant indication for valve surgery or other associated cardiac intervention
Other illness
- Contraindication related to cardiac MRI
- Documented history of atrial fibrillation
Other
- Contraindication related to ILR implantation
- Inability to understand French
- Patient refusal to participate in the study and/or inability to express consent or sign the informed consent form
- Patient subject to legal protection measures
Who the study is looking for
- Age ≥ 18 years
- Indication for surgical myocardial revascularization by isolated coronary artery bypass grafting, to be performed in the cardiac surgery department of Saint-Étienne University Hospital.
- Patient affiliated with or entitled to social security coverage
- Patient who has received informed information about the study and has co-signed, with the investigator, a consent form to participate in the study
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU Saint-Etienne Coordinator of this site? Confirm its status | Saint-Etienne | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.