NCT04664686Recruiting
Rate or Rhythm Control in CRT: the RHYTHMIC Study
Source: ClinicalTrials.gov · Last updated 26 Jan 2026
Brief summary (registry, in English)
70 patients with heart failure, AF and CRT with BiV\<95% will be randomised to either AF ablation or AV node ablation. Evaluation at 6 months with echocardiography and clinical assessment.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 70 (estimated)
- First submitted
- 10 Dec 2020
- Start date
- Oct 2021
- Primary completion date
- Sept 2027
- Lead sponsor
- Guy's and St Thomas' NHS Foundation Trust
- Diseases
- Heart failure, Atrial fibrillation
- NCT number
- NCT04664686
What you commit to
- Study type: Interventional
- Planned participants: 70
- From Oct 2021 to the primary completion date, Sept 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Severe peripheral vascular disease
Other
- Life expectancy \<1 year
- Presence of atrial or ventricular thrombus
- Permanent atrial fibrillation
- Mechanical aortic valve replacement
- Female participants who are pregnant, lactating or planning pregnancy during the course of the study.
- Participation in other studies with active treatment / investigational arm
Who the study is looking for
- Ability to provide informed consent to participate and willing to comply with the clinical investigation plan and follow-up schedule.
- QRS duration \>120ms on surface ECG, severe left ventricular systolic impairment (EF≤35%) and clinical symptoms of heart failure despite optimum medical therapy (NYHA class II-IV) at time of CRT implant or upgrade
- Successful CRT implant or upgrade including atrial lead
- Biventricular pacing percentage \<95% secondary to atrial fibrillation at least 3 months post implant or upgrade
- Clinically indicated for AV node ablation
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Guys and St Thomas NHS Foundation Trust Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.