NCT04674449Recruiting
iCorMicA - Stratified Medicine in Angina
International Study of Coronary Microvascular Angina (iCorMicA): a Randomised, Controlled, Multicentre Trial and Registry
Source: ClinicalTrials.gov · Last updated 9 Apr 2026
Brief summary (registry, in English)
The iCorMicA study is a multicentre, prospective, randomised, double-blind, sham-controlled, parallel-group, end-point trial and registry. The investigators seek to determine whether stratified medical therapy guided by an adjunctive interventional diagnostic procedure (IDP) during the invasive management of patients with known or suspected angina but no obstructive coronary artery disease improves symptoms, wellbeing, cardiovascular risk and clinical outcomes.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 1500 (estimated)
- First submitted
- 24 Jun 2020
- Start date
- Dec 2020
- Primary completion date
- Jun 2026
- Lead sponsor
- NHS Greater Glasgow and Clyde
- Diseases
- Coronary artery disease
- NCT number
- NCT04674449
What you commit to
- Study type: Interventional
- Planned participants: 1500
- From Dec 2020 to the primary completion date, Jun 2026
- 39 sites in 4 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- A non-coronary primary indication for invasive angiography (e.g. valve disease, heart failure).
- History of coronary artery bypass surgery.
- Presence of obstructive disease evident in a main coronary artery (diameter \>2.5 mm), i.e. a coronary stenosis \>50% and/or a fractional flow reserve (FFR) ≤0.80\*.
Other
- Logistical reason\*. \*These patients will enter a follow-up registry.
Who the study is looking for
- Age ≥18 years.
- A clinical plan for invasive coronary angiography.
- Symptoms of angina (typical or atypical) according to the Rose- and/or Seattle Angina questionnaires.
- Able to comply with study procedures.
- Able to provide informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (39)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Aberdeen Royal Hospital Coordinator of this site? Confirm its status | Aberdeen | United Kingdom | Completed |
| William Harvey Hospital Coordinator of this site? Confirm its status | Ashford | United Kingdom | Recruiting |
| Basildon University Hospital - Essex Cardiothoracic Centre Coordinator of this site? Confirm its status | Basildon | United Kingdom | Completed |
| Bedford Hospital NHS Trust Coordinator of this site? Confirm its status | Bedford | United Kingdom | Recruiting |
| Royal Victoria Hospital Coordinator of this site? Confirm its status | Belfast | United Kingdom | Recruiting |
| Birmingham Heartlands Hospital Coordinator of this site? Confirm its status | Birmingham | United Kingdom | Recruiting |
| Royal Blackburn Teaching Hospital Coordinator of this site? Confirm its status | Blackburn | United Kingdom | Recruiting |
| Victoria Hospital Coordinator of this site? Confirm its status | Blackpool | United Kingdom | Recruiting |
| Glan Clwyd Hospital Coordinator of this site? Confirm its status | Bodelwyddan | United Kingdom | Recruiting |
| Royal Bournemouth Hospital Coordinator of this site? Confirm its status | Bournemouth | United Kingdom | Completed |
| Royal Papworth Hospital NHS Foundation Trust Coordinator of this site? Confirm its status | Cambridge | United Kingdom | Active, not recruiting |
| University Hospital of Wales Coordinator of this site? Confirm its status | Cardiff | United Kingdom | Recruiting |
| St Peter's Hospital NHS Foundation Trust Coordinator of this site? Confirm its status | Chertsey | United Kingdom | Recruiting |
| Golden Jubilee National Hospital Coordinator of this site? Confirm its status | Clydebank | United Kingdom | Recruiting |
| University Hospitals Coventry & Warwickshire NHS Trust Coordinator of this site? Confirm its status | Coventry | United Kingdom | Recruiting |
| University Hospital Hairmyres Coordinator of this site? Confirm its status | East Kilbride | United Kingdom | Recruiting |
| NHS Greater Glasgow and Clyde Coordinator of this site? Confirm its status | Glasgow | United Kingdom | Not yet recruiting |
| Raigmore Hospital Coordinator of this site? Confirm its status | Inverness | United Kingdom | Recruiting |
| Leeds Teaching Hospital NHS Trust Coordinator of this site? Confirm its status | Leeds | United Kingdom | Recruiting |
| Liverpool Heart and Chest Hospital Coordinator of this site? Confirm its status | Liverpool | United Kingdom | Recruiting |
| King's College Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| Northwick Park Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| Barts Health NHS Trust St Bartholomew's Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Active, not recruiting |
| Royal Free Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| The Newcastle Upon Tyne Hospitals NHS Foundation Trust Coordinator of this site? Confirm its status | Newcastle upon Tyne | United Kingdom | Recruiting |
| Royal Gwent Hospital Coordinator of this site? Confirm its status | Newport | United Kingdom | Recruiting |
| Nottingham University Hospitals NHS Trust Coordinator of this site? Confirm its status | Nottingham | United Kingdom | Recruiting |
| Queen Alexandra Hospital Coordinator of this site? Confirm its status | Portsmouth | United Kingdom | Recruiting |
| Northern General Hospital Coordinator of this site? Confirm its status | Sheffield | United Kingdom | Recruiting |
| University Hospital Southampton Coordinator of this site? Confirm its status | Southampton | United Kingdom | Recruiting |
| South Tyneside and Sunderland NHS Foundation Trust Coordinator of this site? Confirm its status | Sunderland | United Kingdom | Recruiting |
| Morriston Hospital Coordinator of this site? Confirm its status | Swansea | United Kingdom | Recruiting |
| Pinderfields General Hospital Coordinator of this site? Confirm its status | Wakefield | United Kingdom | Recruiting |
| Watford General Hospital Coordinator of this site? Confirm its status | Watford | United Kingdom | Completed |
| New Cross Hospital Coordinator of this site? Confirm its status | Wolverhampton | United Kingdom | Recruiting |
| Mater Private Hsopital Coordinator of this site? Confirm its status | Cork | Ireland | Completed |
| Mater Private Hospital Coordinator of this site? Confirm its status | Dublin | Ireland | Completed |
| Radboud university medical centre Coordinator of this site? Confirm its status | Nijmegen | Netherlands | Recruiting |
| 5th Military Hospital Coordinator of this site? Confirm its status | Krakow | Poland | Recruiting |
Related publications
- International study of coronary microvascular angina (iCorMicA): A registry-based diagnostic study and nested randomized trial.Am Heart J · 2026 · PMID 42409349
This page is information, not medical advice. Discuss any trial with your doctor.