NCT04675333Active, not recruitingPhase 2
Evorpacept (ALX148) in Combination With Pembrolizumab and Chemotherapy in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-04)
A Phase 2 Study of ALX148 in Combination With Pembrolizumab and Chemotherapy in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-04)
Source: ClinicalTrials.gov · Last updated 3 Aug 2025
Brief summary (registry, in English)
A Phase 2 Study of evorpacept (ALX148) in Combination With pembrolizumab and Chemotherapy in Patients With Advanced Head and Neck Squamous Cell Carcinoma.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 172 (actual)
- First submitted
- 15 Dec 2020
- Start date
- 10 May 2021
- Primary completion date
- 3 Mar 2025
- Lead sponsor
- ALX Oncology Inc.
- Diseases
- Head and neck cancer
- NCT number
- NCT04675333
- EU CT number
- 2023-508342-17-00
- EudraCT number
- 2020-004662-19
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 172
- From 10 May 2021 to the primary completion date, 3 Mar 2025
- 44 sites in 8 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior treatment with any anti-CD47 or anti-SIRPα agent.
- Prior treatment with anti-PD-1 or PD-L1.
Other illness
- Patients with known symptomatic CNS metastases or leptomeningeal disease requiring steroids.
- History of (non-infectious) pneumonitis that required steroids or current pneumonitis.
Who the study is looking for
- Previously untreated metastatic or unresectable, recurrent head and neck squamous cell carcinoma.
- Adequate bone marrow function.
- Adequate renal and liver function.
- Adequate ECOG performance status.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (44)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ashford Cancer Centre Coordinator of this site? Confirm its status | Adelaide | Australia | Unknown status |
| Royal Brisbane and Womens Hospital Coordinator of this site? Confirm its status | Herston | Australia | Unknown status |
| Peter MacCallum Cancer Centre Coordinator of this site? Confirm its status | Melbourne | Australia | Unknown status |
| Sir Charles Gairdner Hospital Coordinator of this site? Confirm its status | Nedlands | Australia | Unknown status |
| Cliniques universitaires Saint-Luc Coordinator of this site? Confirm its status | Brussels | Belgium | Unknown status |
| AZ Groeninge Coordinator of this site? Confirm its status | Kortrijk | Belgium | Unknown status |
| Institut Català d'Oncologia (ICO) Coordinator of this site? Confirm its status | Badalona | Spain | Unknown status |
| Hospital Universitari Dexeus Coordinator of this site? Confirm its status | Barcelona | Spain | Unknown status |
| Hospital Universitario Severo Ochoa Coordinator of this site? Confirm its status | Leganés | Spain | Unknown status |
| Institut Catala dOncologia Coordinator of this site? Confirm its status | L'Hospitalet de Llobregat | Spain | Unknown status |
| Hospital Universitario La Paz Coordinator of this site? Confirm its status | Madrid | Spain | Unknown status |
| Grupo Hospital de Madrid (HM) - Hospital Universitario Madrid Sanchinarro - Cent Coordinator of this site? Confirm its status | Madrid | Spain | Unknown status |
| Hospital Regional Universitario de Malaga Coordinator of this site? Confirm its status | Málaga | Spain | Unknown status |
| Hospital Universitario de Navarra Coordinator of this site? Confirm its status | Pamplona | Spain | Unknown status |
| The Royal Marsden Hospital - Surrey Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| The Royal Marsden Hospital- London Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| University College London Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| Chungbuk National University Hospital Coordinator of this site? Confirm its status | Cheongju-si | South Korea | Unknown status |
| Yeungnam University Medical Center Coordinator of this site? Confirm its status | Daegu | South Korea | Unknown status |
| Gachon University (GCU) - Gil Medical Center (Gil Hospital) Coordinator of this site? Confirm its status | Incheon | South Korea | Unknown status |
| Seoul National University Bundang Hospital Coordinator of this site? Confirm its status | Seongnam | South Korea | Unknown status |
| CHA University - Bundang CHA General Hospital (CHA Bundang Medical Center) Coordinator of this site? Confirm its status | Seongnam-si | South Korea | Unknown status |
| Seoul National University Hospital (SNUH) - SMG-SNU Boramae Medical Center Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
| The Catholic University of Korea, Eunpyeong St. Mary's Hospital Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
| Severance Hospital, Yonsei University Health System Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
| Samsung Medical Center Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
| Seoul National University Hospital Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
| Amsterdam UMC Locatie VUMC Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Unknown status |
| Universitair Medisch Centrum Groningen Coordinator of this site? Confirm its status | Groningen | Netherlands | Unknown status |
| National Cancer Centre Singapore Coordinator of this site? Confirm its status | Singapore | Singapore | Unknown status |
| National University Cancer Institute Coordinator of this site? Confirm its status | Singapore | Singapore | Unknown status |
| University of Maryland Medical System Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Rush University Medical Center Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| The Ohio State University Coordinator of this site? Confirm its status | Columbus | United States | Unknown status |
| Houston Methodist Cancer Center Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Hoag Hospital Coordinator of this site? Confirm its status | Irvine | United States | Unknown status |
| University of California San Diego Coordinator of this site? Confirm its status | La Jolla | United States | Unknown status |
| Cedar Sinai Medical Center Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| University of Louisville Coordinator of this site? Confirm its status | Louisville | United States | Unknown status |
| University of Miami - Sylvester Comprehensive Cancer Center Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| Vanderbilt-Ingram Cancer Center Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
| Memorial Sloan Kettering Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Oregon Health & Science University, Knight Cancer Institute Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
| Moffitt Cancer Center Coordinator of this site? Confirm its status | Tampa | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.