NCT04678869Active, not recruiting
CiproPAL (Ciprofloxacin Prophylaxis in Acute Leukaemia)
CiproPAL (Ciprofloxacin Prophylaxis in Acute Leukaemia): A Randomised Trial to Assess the Use of Ciprofloxacin Prophylaxis to Prevent Bacterial Infection in Children Treated on the Induction Phase of the ALLTogether-1 Treatment Protocol
Source: ClinicalTrials.gov · Last updated 5 Mar 2026
Brief summary (registry, in English)
CiproPAL is a randomised trial comparing daily ciprofloxacin with local standard care during the induction phase of paediatric ALL treatment, and aims: 1. To assess the efficacy of ciprofloxacin prophylaxis in the reduction of infection during the induction phase of treatment for paediatric Acute Lymphoblastic Leukaemia within the ALLTogether-1 Trial. 2. To evaluate the impact of ciprofloxacin prophylaxis on antimicrobial resistance, both of invasive infections and colonising organisms.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 313 (actual)
- First submitted
- 5 Dec 2020
- Start date
- 29 Jun 2022
- Primary completion date
- 1 Jan 2028
- Lead sponsor
- University College, London
- NCT number
- NCT04678869
What you commit to
- Study type: Interventional
- Participants enrolled: 313
- From 29 Jun 2022 to the primary completion date, 1 Jan 2028
- 14 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patients with Down syndrome who already receive ciprofloxacin prophylaxis
Other
- Non-participants of the ALLTogether-1 trial
- Chronic active arthritis
- Other contraindication to fluoroquinolones
Who the study is looking for
- Paediatric patients (1-17 years inclusive) with de-novo Acute Lymphoblastic Leukaemia treated on ALLTogether-1 in the UK in the first 5 days of therapy, up to 14 days is acceptable.
- Written informed consent
Age in the registry: 1 year to 17 years · Sex: All · Does not accept healthy volunteers
Sites (14)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Royal Aberdeen Children's Hospital Coordinator of this site? Confirm its status | Aberdeen | United Kingdom | Unknown status |
| Bristol Royal Hospital for Children Coordinator of this site? Confirm its status | Bristol | United Kingdom | Unknown status |
| Addenbrookes Hospital Coordinator of this site? Confirm its status | Cambridge | United Kingdom | Unknown status |
| Leeds General Infirmary Coordinator of this site? Confirm its status | Leeds | United Kingdom | Unknown status |
| Leicester Royal Infirmary Coordinator of this site? Confirm its status | Leicester | United Kingdom | Unknown status |
| Alder Hey Children's Hospital Coordinator of this site? Confirm its status | Liverpool | United Kingdom | Unknown status |
| Great Ormond Street Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| Univeristy College Hospital London Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| Royal Manchester Children's Hospital Coordinator of this site? Confirm its status | Manchester | United Kingdom | Unknown status |
| Royal Victoria Infirmary Coordinator of this site? Confirm its status | Newcastle | United Kingdom | Unknown status |
| Nottingham Children's Hospital Coordinator of this site? Confirm its status | Nottingham | United Kingdom | Unknown status |
| John Radcliffe Hospital Coordinator of this site? Confirm its status | Oxford | United Kingdom | Unknown status |
| Sheffield Children's Hospital Coordinator of this site? Confirm its status | Sheffield | United Kingdom | Unknown status |
| Southampton General Hospital Coordinator of this site? Confirm its status | Southampton | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.