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NCT04678869Active, not recruiting

CiproPAL (Ciprofloxacin Prophylaxis in Acute Leukaemia)

CiproPAL (Ciprofloxacin Prophylaxis in Acute Leukaemia): A Randomised Trial to Assess the Use of Ciprofloxacin Prophylaxis to Prevent Bacterial Infection in Children Treated on the Induction Phase of the ALLTogether-1 Treatment Protocol

Source: ClinicalTrials.gov · Last updated 5 Mar 2026

Brief summary (registry, in English)

CiproPAL is a randomised trial comparing daily ciprofloxacin with local standard care during the induction phase of paediatric ALL treatment, and aims: 1. To assess the efficacy of ciprofloxacin prophylaxis in the reduction of infection during the induction phase of treatment for paediatric Acute Lymphoblastic Leukaemia within the ALLTogether-1 Trial. 2. To evaluate the impact of ciprofloxacin prophylaxis on antimicrobial resistance, both of invasive infections and colonising organisms.

Status (registry)
Active, not recruiting
Study type
Interventional
Enrollment
313 (actual)
First submitted
5 Dec 2020
Start date
29 Jun 2022
Primary completion date
1 Jan 2028
Lead sponsor
University College, London
NCT number
NCT04678869

What you commit to

  • Study type: Interventional
  • Participants enrolled: 313
  • From 29 Jun 2022 to the primary completion date, 1 Jan 2028
  • 14 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • Patients with Down syndrome who already receive ciprofloxacin prophylaxis

Other

  • Non-participants of the ALLTogether-1 trial
  • Chronic active arthritis
  • Other contraindication to fluoroquinolones

Who the study is looking for

  • Paediatric patients (1-17 years inclusive) with de-novo Acute Lymphoblastic Leukaemia treated on ALLTogether-1 in the UK in the first 5 days of therapy, up to 14 days is acceptable.
  • Written informed consent

Age in the registry: 1 year to 17 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (14)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Royal Aberdeen Children's Hospital
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AberdeenUnited KingdomUnknown status
Bristol Royal Hospital for Children
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BristolUnited KingdomUnknown status
Addenbrookes Hospital
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CambridgeUnited KingdomUnknown status
Leeds General Infirmary
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LeedsUnited KingdomUnknown status
Leicester Royal Infirmary
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LeicesterUnited KingdomUnknown status
Alder Hey Children's Hospital
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LiverpoolUnited KingdomUnknown status
Great Ormond Street Hospital
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LondonUnited KingdomUnknown status
Univeristy College Hospital London
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LondonUnited KingdomUnknown status
Royal Manchester Children's Hospital
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ManchesterUnited KingdomUnknown status
Royal Victoria Infirmary
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NewcastleUnited KingdomUnknown status
Nottingham Children's Hospital
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NottinghamUnited KingdomUnknown status
John Radcliffe Hospital
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OxfordUnited KingdomUnknown status
Sheffield Children's Hospital
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SheffieldUnited KingdomUnknown status
Southampton General Hospital
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SouthamptonUnited KingdomUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.