NCT04681131CompletedPhase 2
CAB-AXL-ADC Safety and Efficacy Study in Adults With NSCLC
A Phase 2 Study of BA3011 Alone and in Combination With PD-1 Inhibitor in Adult Patients With Metastatic Non-small Cell Lung Cancer (NSCLC) Who Had Prior Disease Progression on a PD-1/L-1 Inhibitor, EGFR, or ALK Inhibitor.
Source: ClinicalTrials.gov · Last updated 25 Sept 2025
Brief summary (registry, in English)
The objective of this study is to assess safety and efficacy of CAB-AXL-ADC in NSCLC
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 85 (actual)
- First submitted
- 8 Dec 2020
- Start date
- 17 Mar 2021
- Primary completion date
- 9 Jul 2025
- Lead sponsor
- BioAtla, Inc.
- Diseases
- Lung cancer
- NCT number
- NCT04681131
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 85
- From 17 Mar 2021 to the primary completion date, 9 Jul 2025
- 60 sites in 7 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients must not have had prior therapy with a conjugated or unconjugated auristatin derivative/vinca-binding site targeting payload.
- Patients must not have had major surgery within 4 weeks before first BA3011
Other illness
- Patients must not have clinically significant cardiac disease.
- Patients must not have a history of ≥ Grade 3 allergic reactions to mAb therapy as well as known or suspected allergy or intolerance to any agent given during this study.
- Patients must not have known human immunodeficiency virus (HIV) infection, active hepatitis B and/or hepatitis C.
Other
- Patients must not have known non-controlled CNS metastasis.
- Patients must not be women who are pregnant or breast feeding.
Who the study is looking for
- Patients must have measurable disease.
- Age ≥ 18 years
- Adequate renal function
- Adequate liver function
- Adequate hematological function
- Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
- Life expectancy of at least three months.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (60)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital de la Santa Creu i Sant Pau Coordinator of this site? Confirm its status | Barcelona | Spain | Unknown status |
| Hospital del Mar Coordinator of this site? Confirm its status | Barcelona | Spain | Unknown status |
| Catalan Institute of Oncology, Hospital Duran i Reynals Coordinator of this site? Confirm its status | Barcelona | Spain | Unknown status |
| University Hospital 12 de Octubre Coordinator of this site? Confirm its status | Madrid | Spain | Unknown status |
| Clínica Universidad de navarra Coordinator of this site? Confirm its status | Pamplona | Spain | Unknown status |
| Hospital Universitario Virgen de Valme Coordinator of this site? Confirm its status | Seville | Spain | Unknown status |
| Henry Dunant Hospital Center Coordinator of this site? Confirm its status | Athens | Greece | Unknown status |
| Metropolitan Hospital Perseus Healthcare Group SA Coordinator of this site? Confirm its status | Piraeus | Greece | Unknown status |
| European Interbalkan Medical Center Coordinator of this site? Confirm its status | Thessaloniki | Greece | Unknown status |
| Bioclinic Thessaloniki Coordinator of this site? Confirm its status | Thessaloniki | Greece | Unknown status |
| Queen Mary Hospital Coordinator of this site? Confirm its status | Hong Kong | Hong Kong SAR China | Unknown status |
| ICON Cancer Centre Coordinator of this site? Confirm its status | Hong Kong | Hong Kong SAR China | Unknown status |
| Hong Kong United Oncology Centre Coordinator of this site? Confirm its status | Kowloon | Hong Kong SAR China | Unknown status |
| Hospital San Giuseppe Moscati Coordinator of this site? Confirm its status | Avellino | Italy | Unknown status |
| "IRCCS Osp. Policlinico San Martino Pad Ex microbiologia, stanza 9, 1 piano." Coordinator of this site? Confirm its status | Genoa | Italy | Unknown status |
| European Institute of Oncology (IEO), IRCCS Coordinator of this site? Confirm its status | Milan | Italy | Unknown status |
| Santa Maria delle Croci Hospital of Ravenna Coordinator of this site? Confirm its status | Ravenna | Italy | Unknown status |
| Integrated University Hospital of Verona Coordinator of this site? Confirm its status | Verona | Italy | Unknown status |
| Polish Mother's Memorial Hospital - Research Institute Coordinator of this site? Confirm its status | Lodz | Poland | Unknown status |
| Institute of Genetics and Immunology GENIM Coordinator of this site? Confirm its status | Lublin | Poland | Unknown status |
| MED-Polonia, Sp. z o.o. (LLC) Coordinator of this site? Confirm its status | Poznan | Poland | Unknown status |
| Specialistic Oncologic Hospital NU-MED Coordinator of this site? Confirm its status | Tomaszów Mazowiecki | Poland | Unknown status |
| Maria Sklodowska-Curie - National Research Institute of Oncology Coordinator of this site? Confirm its status | Warsaw | Poland | Unknown status |
| Kaoshiung Chang Gung Memorial Hospital Coordinator of this site? Confirm its status | Kaohsiung City | Taiwan | Unknown status |
| Taichung Veterans General Hospital Coordinator of this site? Confirm its status | Taichung | Taiwan | Unknown status |
| National Cheng Kung University Hospital Coordinator of this site? Confirm its status | Tainan | Taiwan | Unknown status |
| National Taiwan University Hospital Coordinator of this site? Confirm its status | Taipei | Taiwan | Unknown status |
| Taipei Veterans General Hospital Coordinator of this site? Confirm its status | Taipei | Taiwan | Unknown status |
| Augusta University, Georgia Cancer Center Coordinator of this site? Confirm its status | Augusta | United States | Unknown status |
| University of Colorado Anschutz Medical Campus Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
| Hematology/Oncology Clinic Coordinator of this site? Confirm its status | Baton Rouge | United States | Unknown status |
| Dana-Farber Cancer Institute Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Roswell Park Coordinator of this site? Confirm its status | Buffalo | United States | Unknown status |
| Gabrail Cancer & Research Center Coordinator of this site? Confirm its status | Canton | United States | Unknown status |
| Medical University of South Carolina - Hollings Cancer Center Coordinator of this site? Confirm its status | Charleston | United States | Unknown status |
| The Lindner Research Center at the Christ Hospital Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
| Mary Crowley Cancer Research Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| University of Michigan Comprehensive Cancer Center Coordinator of this site? Confirm its status | Detroit | United States | Unknown status |
| City of Hope - Duarte Coordinator of this site? Confirm its status | Duarte | United States | Unknown status |
| Florida Cancer Specialists & Research Institute Coordinator of this site? Confirm its status | Fleming Island | United States | Unknown status |
| Florida Cancer Specialists & Research Institute Coordinator of this site? Confirm its status | Fort Myers | United States | Unknown status |
| Comprehensive Cancer Centers of Nevada Coordinator of this site? Confirm its status | Henderson | United States | Unknown status |
| MD Anderson Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| University of California Irvine Medical Center (UCIMC) - Chao Family Comprehensive Cancer Center Coordinator of this site? Confirm its status | Irvine | United States | Unknown status |
| OptumCare Cancer Care Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| University of Kentucky Coordinator of this site? Confirm its status | Lexington | United States | Unknown status |
| Baptist Health Systems Coordinator of this site? Confirm its status | Lexington | United States | Unknown status |
| USC Norris Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| Cedars Sinai Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| California Research Institute Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| Norton Cancer Institute, Brownsboro Hospital Campus Coordinator of this site? Confirm its status | Louisville | United States | Unknown status |
| Sarah Cannon Research Institute Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
| NYU Langone Health Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| FirstHealth Outpatient Cancer Center Coordinator of this site? Confirm its status | Pinehurst | United States | Unknown status |
| UPMC Cancer Center Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| University of California, San Diego (UCSD) - Moores Cancer Center Coordinator of this site? Confirm its status | San Diego | United States | Unknown status |
| Florida Cancer Specialist Coordinator of this site? Confirm its status | St. Petersburg | United States | Unknown status |
| Moffitt Cancer Center Coordinator of this site? Confirm its status | Tampa | United States | Unknown status |
| Florida Cancer Specialists Coordinator of this site? Confirm its status | West Palm Beach | United States | Unknown status |
| American Institute of Research Coordinator of this site? Confirm its status | Whittier | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.