NCT04681807Completed
Social Cognition in Youth Who Have a First Degree Relative With Schizophrenia
Source: ClinicalTrials.gov · Last updated 2 Jan 2026
Brief summary (registry, in English)
Social cognition is an individual's ability to perceive, process, understand, and react to other individuals in a social situation. Social cognition is impaired in individuals with schizophrenia, including difficulty recognizing others' emotions. A promising treatment avenue for emotion recognition problems in individuals with schizophrenia is continued practice with various facial expression recognition training programs. First degree relatives of someone with schizophrenia are considered at familial high risk (FHR) for the illness, because of its high level of heritability. It is therefore critical to explore if these emotion recognition training programs could also benefit people at FHR. In this current study, the investigators aim to explore the social-cognitive profiles and their neural correlates in FHR individuals. The investigators also aim to explore the potential efficacy of an emotion recognition intervention to improve this ability in FHR individuals.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 82 (actual)
- First submitted
- 18 Dec 2020
- Start date
- 21 Jul 2021
- Primary completion date
- 22 Aug 2025
- Lead sponsor
- The Royal Ottawa Mental Health Centre
- Diseases
- Schizophrenia
- NCT number
- NCT04681807
What you commit to
- Study type: Interventional
- Participants enrolled: 82
- From 21 Jul 2021 to the primary completion date, 22 Aug 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current epilepsy or previous history of seizures
- Previous head injury with current continuing symptoms (i.e., cognitive ability, dizziness, etc.)
Other illness
- No diagnosis of psychosis related disorder
- Significant neurological or medical disorders that may produce cognitive impairment
- Recent history of substance abuse or dependence (within past 3 months)
- MRI contraindication (e.g. metallic head implant, history of seizure, pacemaker, pregnancy, etc.)
Other
- Current IQ \< 70 as measured by the Wechsler Abbreviated Scale of Intelligence Scale (WASI)
Who the study is looking for
- Between (or equal to) 15-35 years of age
- Ability to read/speak fluent English
- Diagnosis of SZ, schizoaffective disorder or schizophreniform confirmed for 1st degree relative by referring psychiatrist or two reliable informants (using the adapted FIGS questionnaire).
Age in the registry: 15 years to 35 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The Royal Ottawa Mental Health Centre Coordinator of this site? Confirm its status | Ottawa | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.