NCT04682769Completed
Cardiac Markers in Depressed Patients With Coronary Heart Disease - R01HL147862
Fatigue, Anhedonia and Cardiac Prognostic Markers in Depressed Patients With Coronary Heart Disease
Source: ClinicalTrials.gov · Last updated 24 Dec 2025
Brief summary (registry, in English)
Depression doubles the risk of death in patients with coronary heart disease (CHD), but so far, there is insufficient evidence that we can reduce the risk of death by treating depression. This study will investigate the cardiac risk markers that are associated with depression symptoms that remain despite treatment, and identify potential targets for their treatment. The results of the study will inform the development of more effective interventions to improve both depression and survival in patients with CHD.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 175 (actual)
- First submitted
- 10 Dec 2020
- Start date
- 1 Dec 2020
- Primary completion date
- 25 Jan 2025
- Lead sponsor
- Washington University School of Medicine
- Diseases
- Coronary artery disease
- NCT number
- NCT04682769
What you commit to
- Study type: Observational
- Participants enrolled: 175
- From 1 Dec 2020 to the primary completion date, 25 Jan 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Taking antidepressants other than a selective serotonin reuptake inhibitor (SSRI).
Other illness
- Thyroid disease or thyroid medications.
- Moderate to severe cognitive impairment.
- Major psychiatric comorbidities.
- New York Heart Association (NYHA) class III or higher or a recent (\<3 months) acute coronary syndrome (ACS), coronary artery bypass graft surgery, cardiac hospitalization, or cardiac-related emergency department visit.
- Advanced malignancy, a disability that would prevent compliance with the study protocol, or physician or patient refusal.
Other
- Suicidal features.
- Current substance abuse.
Who the study is looking for
- Patients seen at the Washington University Medical Center with coronary heart disease (CHD) documented by coronary angiography or history of acute coronary syndrome (ACS).
- On a stable medication regimen (only minor changes in drug or dosage in last 30 days) are eligible for recruitment.
- Meet the diagnostic criteria for a depressive disorder, score ≥ 14 on the Beck Depression Inventory (BDI-II), and not meet any exclusion criteria.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Washington University Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.